MKI67 [The Human Chemical-Genetic Interaction Map Project]

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======= MKI67 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MKI67
  * **<color #00a2e8>Official Name</color>**: marker of proliferation Ki-67
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4288|4288]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46013|P46013]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MKI67&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MKI67|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176741|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|K167R|
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed chromosome|
|regulation of chromosome segregation|
|regulation of mitotic nuclear division|
|regulation of chromatin organization|
|protein C-terminus binding|
|regulation of nuclear division|
|nuclear body|
|regulation of chromosome organization|
|cell population proliferation|
|regulation of mitotic cell cycle|
|regulation of cell cycle process|
|nucleolus|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|DNA binding|
|ATP binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.56|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.02|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.74|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.81|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.87|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.95|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MKI67 Expression in NALM6 Cells: 10.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>