Show pageOld revisionsBacklinksFold/unfold allBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ======= MLXIP ======= == Gene Information == * **<color #00a2e8>Official Symbol</color>**: MLXIP * **<color #00a2e8>Official Name</color>**: MLX interacting protein * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22877|22877]] * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAP2|Q9HAP2]] * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLXIP&organism=9606|BioGRID]] * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLXIP|Open PubMed]] * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608090|Open OMIM]] == Function Summary == * **<color #00a2e8>Entrez Summary</color>**: This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]. * **<color #00a2e8>UniProt Summary</color>**: Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. <button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button> <button type='primary' size='sm' modal='GO_terms'>GO Terms</button> <modal id='Pfam_Domains' size='lg' title='Pfam Domains'> |HLH| </modal> <modal id='GO_terms' size='lg' title='GO Terms'> |regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter| |protein dimerization activity| |mitochondrial outer membrane| |regulation of carbohydrate metabolic process| |RNA polymerase II regulatory region sequence-specific DNA binding| |DNA-binding transcription activator activity, RNA polymerase II-specific| |DNA-binding transcription factor activity| |positive regulation of transcription by RNA polymerase II| |positive regulation of transcription, DNA-templated| |DNA-binding transcription factor activity, RNA polymerase II-specific| |positive regulation of nucleic acid-templated transcription| |positive regulation of RNA biosynthetic process| |positive regulation of RNA metabolic process| |positive regulation of nucleobase-containing compound metabolic process| |positive regulation of macromolecule biosynthetic process| |positive regulation of cellular biosynthetic process| |positive regulation of gene expression| |positive regulation of biosynthetic process| </modal> \\ === CRISPR Data === <button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button> <button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button> <button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button> <modal id='Compound_Hit' size='lg' title='Compound Hit'> ^Screen^Score^ |[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.81| |[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.85| |[[:results:exp492|iCRT14 30μM R08 exp492]]|1.98| |[[:results:exp211|AICAR 240μM R05 exp211]]|2.04| |[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|6.25| </modal> <modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'> ^Gene^Correlation^ |[[:human genes:m:mlx|MLX]]|0.664| |[[:human genes:t:txnip|TXNIP]]|0.621| </modal> <modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'> Global Fraction of Cell Lines Where Essential: N/A ^Tissue^Fraction Of Cell Lines Where Essential^ </modal> == Essentiality in NALM6 == * **<color #00a2e8>Essentiality Rank</color>**: 18378 * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.05 <button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button> <modal id='Dist_expr' size='lg' title='MLXIP Expression in NALM6 Cells: 8.05'> {{:chemogenomics:nalm6 dist.png?nolink |}} </modal> Last modified: 2025/12/10 20:19by 127.0.0.1