MMP12 [The Human Chemical-Genetic Interaction Map Project]

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======= MMP12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP12
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4321|4321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P39900|P39900]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PG binding 1|
|Peptidase M10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endothelial cell-matrix adhesion via fibronectin|
|regulation of endothelial cell-matrix adhesion via fibronectin|
|elastin catabolic process|
|elastin metabolic process|
|positive regulation of epithelial cell proliferation involved in wound healing|
|wound healing, spreading of epidermal cells|
|positive regulation of interferon-alpha secretion|
|regulation of interferon-alpha secretion|
|positive regulation of type I interferon-mediated signaling pathway|
|core promoter binding|
|negative regulation of type I interferon-mediated signaling pathway|
|glycoprotein catabolic process|
|positive regulation of interferon-alpha production|
|wound healing, spreading of cells|
|epiboly involved in wound healing|
|epiboly|
|regulation of interferon-alpha production|
|cellular response to virus|
|regulation of type I interferon-mediated signaling pathway|
|regulation of defense response to virus by host|
|negative regulation of cell-matrix adhesion|
|collagen catabolic process|
|morphogenesis of an epithelial sheet|
|response to amyloid-beta|
|positive regulation of cytokine-mediated signaling pathway|
|negative regulation of innate immune response|
|positive regulation of response to cytokine stimulus|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of cell-substrate adhesion|
|collagen binding|
|extracellular matrix disassembly|
|negative regulation of response to cytokine stimulus|
|collagen metabolic process|
|regulation of defense response to virus|
|endopeptidase activity|
|positive regulation of type I interferon production|
|negative regulation of response to biotic stimulus|
|protein import into nucleus|
|metalloendopeptidase activity|
|regulation of cell-matrix adhesion|
|import into nucleus|
|regulation of type I interferon production|
|positive regulation of cytokine secretion|
|protein import|
|negative regulation of immune response|
|protein localization to nucleus|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of epithelial cell proliferation|
|carbohydrate derivative catabolic process|
|regulation of cytokine secretion|
|negative regulation of defense response|
|regulation of cell-substrate adhesion|
|negative regulation of multi-organism process|
|extracellular matrix|
|nucleocytoplasmic transport|
|nuclear transport|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|response to virus|
|positive regulation of peptide secretion|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|glycoprotein metabolic process|
|extracellular structure organization|
|cellular component disassembly|
|positive regulation of secretion by cell|
|sequence-specific DNA binding|
|positive regulation of protein transport|
|morphogenesis of an epithelium|
|establishment of protein localization to organelle|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|response to peptide|
|positive regulation of defense response|
|wound healing|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|tissue morphogenesis|
|response to wounding|
|positive regulation of response to external stimulus|
|regulation of cell adhesion|
|protein catabolic process|
|regulation of cytokine production|
|regulation of protein transport|
|calcium ion binding|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of secretion|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|cell migration|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|epithelium development|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.79|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.75|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18626
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP12 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>