MMP8 [The Human Chemical-Genetic Interaction Map Project]

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======= MMP8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP8
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4317|4317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22894|P22894]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120355|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Can degrade fibrillar type I, II, and III collagens.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M10|
|PG binding 1|
|Hemopexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microglial cell activation|
|positive regulation of neuroinflammatory response|
|regulation of microglial cell activation|
|negative regulation of interleukin-10 production|
|positive regulation of tumor necrosis factor secretion|
|positive regulation of macrophage activation|
|regulation of tumor necrosis factor secretion|
|regulation of neuroinflammatory response|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|endodermal cell differentiation|
|collagen catabolic process|
|endoderm formation|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of interleukin-10 production|
|regulation of macrophage activation|
|tertiary granule lumen|
|positive regulation of DNA binding|
|regulation of nitric oxide biosynthetic process|
|specific granule lumen|
|extracellular matrix disassembly|
|collagen metabolic process|
|endoderm development|
|endopeptidase activity|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of interleukin-6 production|
|positive regulation of reactive oxygen species metabolic process|
|metalloendopeptidase activity|
|regulation of NIK/NF-kappaB signaling|
|formation of primary germ layer|
|regulation of DNA binding|
|positive regulation of cytokine secretion|
|positive regulation of JNK cascade|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|gastrulation|
|serine-type endopeptidase activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of binding|
|regulation of reactive oxygen species metabolic process|
|regulation of JNK cascade|
|regulation of cytokine secretion|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|regulation of inflammatory response|
|extracellular matrix organization|
|regulation of neurotransmitter levels|
|collagen-containing extracellular matrix|
|regulation of binding|
|extracellular structure organization|
|cellular component disassembly|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of MAPK cascade|
|embryonic morphogenesis|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|exocytosis|
|regulation of secretion|
|zinc ion binding|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|embryo development|
|positive regulation of transport|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|proteolysis|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.83|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.82|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.81|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.99|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18684
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP8 Expression in NALM6 Cells: -0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>