MNS1 [The Human Chemical-Genetic Interaction Map Project]

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======= MNS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MNS1
  * **<color #00a2e8>Official Name</color>**: meiosis specific nuclear structural 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55329|55329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEH6|Q8NEH6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MNS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MNS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|left/right axis specification|
|left/right pattern formation|
|positive regulation of cilium assembly|
|sperm flagellum|
|positive regulation of organelle assembly|
|regulation of cilium assembly|
|axis specification|
|motile cilium|
|positive regulation of plasma membrane bounded cell projection assembly|
|axoneme|
|intermediate filament|
|nuclear envelope|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|meiotic cell cycle|
|regionalization|
|cilium organization|
|positive regulation of cell projection organization|
|pattern specification process|
|positive regulation of cellular component biogenesis|
|spermatogenesis|
|male gamete generation|
|positive regulation of organelle organization|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cellular component biogenesis|
|multi-organism reproductive process|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-3.11|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.58|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.51|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.37|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.28|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.24|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.2|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.14|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.08|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.98|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.93|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.93|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.91|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.91|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.83|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.8|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.75|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.73|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.71|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.78|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.01|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.24|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18847
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MNS1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>