MON2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= MON2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MON2
  * **<color #00a2e8>Official Name</color>**: MON2 homolog, regulator of endosome-to-Golgi trafficking
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23041|23041]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3U7|Q7Z3U7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MON2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MON2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616822|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec7 N|
|DUF1981|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi to endosome transport|
|post-Golgi vesicle-mediated transport|
|cytosolic transport|
|Golgi vesicle transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.53|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.51|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.29|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.24|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.16|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.04|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.95|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.87|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.82|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.79|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.76|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.75|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.73|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2195
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MON2 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>