MOS [The Human Chemical-Genetic Interaction Map Project]

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======= MOS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MOS
  * **<color #00a2e8>Official Name</color>**: MOS proto-oncogene, serine/threonine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4342|4342]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00540|P00540]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MOS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MOS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of meiotic spindle orientation|
|negative regulation of metaphase/anaphase transition of meiotic cell cycle|
|negative regulation of meiotic chromosome separation|
|negative regulation of meiotic cell cycle phase transition|
|regulation of metaphase/anaphase transition of meiotic cell cycle|
|regulation of meiotic chromosome separation|
|establishment of meiotic spindle localization|
|regulation of meiotic cell cycle phase transition|
|negative regulation of meiotic nuclear division|
|meiotic spindle organization|
|negative regulation of meiotic cell cycle|
|MAP kinase kinase kinase activity|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of chromosome separation|
|regulation of meiotic nuclear division|
|negative regulation of chromosome segregation|
|establishment of spindle orientation|
|establishment of spindle localization|
|spindle localization|
|negative regulation of nuclear division|
|regulation of meiotic cell cycle|
|regulation of metaphase/anaphase transition of cell cycle|
|activation of MAPKK activity|
|negative regulation of reproductive process|
|regulation of chromosome separation|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|establishment of cell polarity|
|spindle organization|
|activation of MAPK activity|
|regulation of reproductive process|
|meiotic cell cycle process|
|regulation of nuclear division|
|protein autophosphorylation|
|establishment or maintenance of cell polarity|
|meiotic cell cycle|
|negative regulation of cell cycle phase transition|
|positive regulation of MAP kinase activity|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of chromosome organization|
|establishment of organelle localization|
|protein serine/threonine kinase activity|
|MAPK cascade|
|negative regulation of organelle organization|
|signal transduction by protein phosphorylation|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|organelle localization|
|positive regulation of transferase activity|
|microtubule-based process|
|chromatin organization|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|chromosome organization|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.7|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.87|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MOS Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>