MOSPD2 [The Human Chemical-Genetic Interaction Map Project]

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======= MOSPD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MOSPD2
  * **<color #00a2e8>Official Name</color>**: motile sperm domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=158747|158747]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHP6|Q8NHP6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MOSPD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MOSPD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301086|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes migration of primary monocytes and neutrophils, in response to various chemokines. {ECO:0000269|PubMed:28137892}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CRAL TRIO|
|Motile Sperm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of monocyte chemotaxis|
|positive regulation of mononuclear cell migration|
|positive regulation of neutrophil chemotaxis|
|regulation of monocyte chemotaxis|
|positive regulation of granulocyte chemotaxis|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|regulation of neutrophil migration|
|regulation of granulocyte chemotaxis|
|regulation of mononuclear cell migration|
|positive regulation of leukocyte chemotaxis|
|specific granule membrane|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cell migration|
|regulation of cell motility|
|leukocyte activation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|locomotion|
|integral component of plasma membrane|
|regulation of immune system process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.24|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.9|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.85|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.76|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.76|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.71|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.94|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MOSPD2 Expression in NALM6 Cells: 4.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>