MPHOSPH8 [The Human Chemical-Genetic Interaction Map Project]

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======= MPHOSPH8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPHOSPH8
  * **<color #00a2e8>Official Name</color>**: M-phase phosphoprotein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54737|54737]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99549|Q99549]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPHOSPH8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPHOSPH8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611626|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Chromo|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of methylation-dependent chromatin silencing|
|regulation of methylation-dependent chromatin silencing|
|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|positive regulation of chromatin silencing|
|nuclear nucleosome|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|nuclear heterochromatin|
|regulation of DNA methylation|
|heterochromatin|
|regulation of chromatin silencing|
|negative regulation of viral genome replication|
|methylated histone binding|
|negative regulation of gene expression, epigenetic|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|positive regulation of chromatin organization|
|regulation of gene silencing|
|regulation of viral life cycle|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of gene expression, epigenetic|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|chromatin binding|
|positive regulation of organelle organization|
|regulation of multi-organism process|
|nucleolus|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.62|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.39|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.22|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.17|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-2.02|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.79|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.77|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.7|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.74|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.96|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.22|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam208a|FAM208A]]|0.48|
|[[:human genes:p:pphln1|PPHLN1]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPHOSPH8 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>