MRPL11 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL11
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65003|65003]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3B7|Q9Y3B7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611826|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L11|
|Ribosomal L11 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|large ribosomal subunit rRNA binding|
|large ribosomal subunit|
|mitochondrial ribosome|
|ribosomal large subunit assembly|
|rRNA binding|
|mitochondrial large ribosomal subunit|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.84|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.81|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.76|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.74|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.72|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.92|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.1|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.1|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.18|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.591|
|[[:human genes:y:yars2|YARS2]]|0.566|
|[[:human genes:t:tars2|TARS2]]|0.536|
|[[:human genes:m:mrps6|MRPS6]]|0.526|
|[[:human genes:m:mrps34|MRPS34]]|0.526|
|[[:human genes:c:coa3|COA3]]|0.524|
|[[:human genes:q:qrsl1|QRSL1]]|0.512|
|[[:human genes:m:mrpl23|MRPL23]]|0.51|
|[[:human genes:m:mrps21|MRPS21]]|0.509|
|[[:human genes:s:sco2|SCO2]]|0.501|
|[[:human genes:g:gfm1|GFM1]]|0.501|
|[[:human genes:m:mrps16|MRPS16]]|0.5|
|[[:human genes:p:polg|POLG]]|0.5|
|[[:human genes:s:selrc1|SELRC1]]|0.499|
|[[:human genes:n:nars2|NARS2]]|0.498|
|[[:human genes:g:gfm2|GFM2]]|0.496|
|[[:human genes:p:pars2|PARS2]]|0.494|
|[[:human genes:r:rpusd4|RPUSD4]]|0.489|
|[[:human genes:m:mrpl21|MRPL21]]|0.487|
|[[:human genes:m:mrpl53|MRPL53]]|0.486|
|[[:human genes:f:fastkd5|FASTKD5]]|0.484|
|[[:human genes:p:pet117|PET117]]|0.484|
|[[:human genes:d:dars2|DARS2]]|0.483|
|[[:human genes:c:c12orf65|C12orf65]]|0.483|
|[[:human genes:m:mrpl37|MRPL37]]|0.482|
|[[:human genes:t:tomm20|TOMM20]]|0.481|
|[[:human genes:e:ears2|EARS2]]|0.48|
|[[:human genes:r:rars2|RARS2]]|0.479|
|[[:human genes:n:ndufb11|NDUFB11]]|0.475|
|[[:human genes:w:wbscr16|WBSCR16]]|0.472|
|[[:human genes:m:mrps26|MRPS26]]|0.471|
|[[:human genes:r:rbfa|RBFA]]|0.47|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.469|
|[[:human genes:c:cox11|COX11]]|0.467|
|[[:human genes:m:mrpl15|MRPL15]]|0.467|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.466|
|[[:human genes:m:mrpl43|MRPL43]]|0.466|
|[[:human genes:m:mrps14|MRPS14]]|0.465|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.464|
|[[:human genes:c:coa6|COA6]]|0.463|
|[[:human genes:m:mtpap|MTPAP]]|0.462|
|[[:human genes:m:mrpl3|MRPL3]]|0.461|
|[[:human genes:m:mrps18a|MRPS18A]]|0.461|
|[[:human genes:m:mrps5|MRPS5]]|0.459|
|[[:human genes:m:mrp63|MRP63]]|0.458|
|[[:human genes:l:lars2|LARS2]]|0.458|
|[[:human genes:c:cox5a|COX5A]]|0.456|
|[[:human genes:n:ndufa3|NDUFA3]]|0.455|
|[[:human genes:m:mrps2|MRPS2]]|0.452|
|[[:human genes:d:dap3|DAP3]]|0.449|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.448|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.447|
|[[:human genes:b:bcs1l|BCS1L]]|0.446|
|[[:human genes:m:mrpl20|MRPL20]]|0.444|
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:t:tefm|TEFM]]|0.442|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.441|
|[[:human genes:m:mars2|MARS2]]|0.441|
|[[:human genes:m:mrps22|MRPS22]]|0.441|
|[[:human genes:c:c10orf2|C10orf2]]|0.439|
|[[:human genes:n:ndufa2|NDUFA2]]|0.438|
|[[:human genes:m:mrpl45|MRPL45]]|0.436|
|[[:human genes:f:fastkd1|FASTKD1]]|0.436|
|[[:human genes:m:mtg2|MTG2]]|0.435|
|[[:human genes:p:pet112|PET112]]|0.434|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.434|
|[[:human genes:c:cox17|COX17]]|0.434|
|[[:human genes:v:vars2|VARS2]]|0.434|
|[[:human genes:m:mrpl42|MRPL42]]|0.434|
|[[:human genes:m:mrps24|MRPS24]]|0.434|
|[[:human genes:a:aifm1|AIFM1]]|0.434|
|[[:human genes:p:ptcd3|PTCD3]]|0.432|
|[[:human genes:n:ndufb3|NDUFB3]]|0.43|
|[[:human genes:m:mrpl17|MRPL17]]|0.43|
|[[:human genes:p:polg2|POLG2]]|0.429|
|[[:human genes:p:polrmt|POLRMT]]|0.428|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.427|
|[[:human genes:a:alg8|ALG8]]|0.427|
|[[:human genes:f:ftsj2|FTSJ2]]|0.426|
|[[:human genes:m:mrps9|MRPS9]]|0.423|
|[[:human genes:m:mrpl12|MRPL12]]|0.423|
|[[:human genes:m:mtg1|MTG1]]|0.423|
|[[:human genes:m:malsu1|MALSU1]]|0.421|
|[[:human genes:c:cars2|CARS2]]|0.42|
|[[:human genes:g:gatc|GATC]]|0.419|
|[[:human genes:m:mrps27|MRPS27]]|0.418|
|[[:human genes:w:wars2|WARS2]]|0.416|
|[[:human genes:c:cox7b|COX7B]]|0.414|
|[[:human genes:c:c17orf89|C17orf89]]|0.413|
|[[:human genes:m:mrps25|MRPS25]]|0.41|
|[[:human genes:m:mrps12|MRPS12]]|0.41|
|[[:human genes:c:cox15|COX15]]|0.41|
|[[:human genes:s:sars2|SARS2]]|0.408|
|[[:human genes:d:dhrsx|DHRSX]]|0.406|
|[[:human genes:m:mrpl34|MRPL34]]|0.404|
|[[:human genes:m:mrpl55|MRPL55]]|0.404|
|[[:human genes:h:hars2|HARS2]]|0.403|
|[[:human genes:m:mrpl47|MRPL47]]|0.4|
|[[:human genes:m:mrps33|MRPS33]]|0.4|
|[[:human genes:i:iba57|IBA57]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2304
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL11 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>