MRPL13 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL13
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28998|28998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYD1|Q9BYD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610200|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|negative regulation of translation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|negative regulation of cellular amide metabolic process|
|mRNA binding|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|regulation of translation|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|mitochondrion|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.83|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.86|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mettl17|METTL17]]|0.55|
|[[:human genes:n:ndufb9|NDUFB9]]|0.541|
|[[:human genes:n:ndufa3|NDUFA3]]|0.528|
|[[:human genes:d:dap3|DAP3]]|0.515|
|[[:human genes:n:ndufb11|NDUFB11]]|0.506|
|[[:human genes:m:mrpl21|MRPL21]]|0.499|
|[[:human genes:m:mrp63|MRP63]]|0.498|
|[[:human genes:n:ndufc2|NDUFC2]]|0.496|
|[[:human genes:m:mrps25|MRPS25]]|0.495|
|[[:human genes:v:vars2|VARS2]]|0.495|
|[[:human genes:m:mrpl45|MRPL45]]|0.494|
|[[:human genes:p:pet112|PET112]]|0.494|
|[[:human genes:m:mrpl47|MRPL47]]|0.489|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.489|
|[[:human genes:n:ndufa2|NDUFA2]]|0.487|
|[[:human genes:m:mrps16|MRPS16]]|0.485|
|[[:human genes:m:mrps21|MRPS21]]|0.484|
|[[:human genes:n:ndufb4|NDUFB4]]|0.481|
|[[:human genes:c:chchd1|CHCHD1]]|0.477|
|[[:human genes:f:fars2|FARS2]]|0.476|
|[[:human genes:c:cox16|COX16]]|0.475|
|[[:human genes:n:ndufb7|NDUFB7]]|0.474|
|[[:human genes:n:ndufb6|NDUFB6]]|0.474|
|[[:human genes:d:ddx28|DDX28]]|0.473|
|[[:human genes:n:nars2|NARS2]]|0.473|
|[[:human genes:n:ndufa11|NDUFA11]]|0.471|
|[[:human genes:m:mrps14|MRPS14]]|0.47|
|[[:human genes:n:ndufs2|NDUFS2]]|0.468|
|[[:human genes:t:tufm|TUFM]]|0.468|
|[[:human genes:f:ftsj2|FTSJ2]]|0.468|
|[[:human genes:n:ndufa1|NDUFA1]]|0.466|
|[[:human genes:m:mrps10|MRPS10]]|0.465|
|[[:human genes:r:rbfa|RBFA]]|0.464|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.459|
|[[:human genes:w:wbscr16|WBSCR16]]|0.459|
|[[:human genes:m:mrps18a|MRPS18A]]|0.458|
|[[:human genes:g:gfm1|GFM1]]|0.458|
|[[:human genes:a:acad9|ACAD9]]|0.455|
|[[:human genes:p:ptcd3|PTCD3]]|0.455|
|[[:human genes:r:rpusd4|RPUSD4]]|0.453|
|[[:human genes:h:hars2|HARS2]]|0.451|
|[[:human genes:m:mto1|MTO1]]|0.451|
|[[:human genes:m:mrps35|MRPS35]]|0.449|
|[[:human genes:n:ndufs7|NDUFS7]]|0.448|
|[[:human genes:t:trub2|TRUB2]]|0.447|
|[[:human genes:y:yars2|YARS2]]|0.447|
|[[:human genes:p:pars2|PARS2]]|0.446|
|[[:human genes:n:ndufv1|NDUFV1]]|0.445|
|[[:human genes:r:rars2|RARS2]]|0.445|
|[[:human genes:m:mrpl23|MRPL23]]|0.444|
|[[:human genes:m:mrps5|MRPS5]]|0.443|
|[[:human genes:m:mrps12|MRPS12]]|0.442|
|[[:human genes:m:mrps6|MRPS6]]|0.442|
|[[:human genes:m:mrpl38|MRPL38]]|0.442|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.441|
|[[:human genes:m:mrpl42|MRPL42]]|0.441|
|[[:human genes:m:mrps7|MRPS7]]|0.44|
|[[:human genes:m:mars2|MARS2]]|0.439|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.437|
|[[:human genes:t:tars2|TARS2]]|0.437|
|[[:human genes:m:mrps9|MRPS9]]|0.436|
|[[:human genes:m:mrpl12|MRPL12]]|0.435|
|[[:human genes:m:mrps23|MRPS23]]|0.434|
|[[:human genes:e:ecsit|ECSIT]]|0.433|
|[[:human genes:m:mtg2|MTG2]]|0.432|
|[[:human genes:s:sco2|SCO2]]|0.431|
|[[:human genes:m:mrpl3|MRPL3]]|0.431|
|[[:human genes:p:pnpt1|PNPT1]]|0.43|
|[[:human genes:s:selrc1|SELRC1]]|0.43|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.43|
|[[:human genes:l:lars2|LARS2]]|0.43|
|[[:human genes:n:nubpl|NUBPL]]|0.429|
|[[:human genes:m:mterfd1|MTERFD1]]|0.428|
|[[:human genes:e:eral1|ERAL1]]|0.427|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.427|
|[[:human genes:n:ndufc1|NDUFC1]]|0.426|
|[[:human genes:f:fastkd5|FASTKD5]]|0.425|
|[[:human genes:c:coq2|COQ2]]|0.424|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.424|
|[[:human genes:t:tfam|TFAM]]|0.423|
|[[:human genes:q:qrsl1|QRSL1]]|0.422|
|[[:human genes:m:mrpl44|MRPL44]]|0.421|
|[[:human genes:d:dhx30|DHX30]]|0.421|
|[[:human genes:m:mtg1|MTG1]]|0.418|
|[[:human genes:m:mrpl53|MRPL53]]|0.418|
|[[:human genes:m:mrps34|MRPS34]]|0.416|
|[[:human genes:m:mrpl15|MRPL15]]|0.414|
|[[:human genes:f:fastkd2|FASTKD2]]|0.413|
|[[:human genes:m:mipep|MIPEP]]|0.413|
|[[:human genes:m:mrps26|MRPS26]]|0.412|
|[[:human genes:m:mrpl14|MRPL14]]|0.412|
|[[:human genes:m:mrpl43|MRPL43]]|0.411|
|[[:human genes:g:gfm2|GFM2]]|0.411|
|[[:human genes:m:mrpl55|MRPL55]]|0.408|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.406|
|[[:human genes:d:dars2|DARS2]]|0.405|
|[[:human genes:c:cox17|COX17]]|0.404|
|[[:human genes:m:mrpl33|MRPL33]]|0.404|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.403|
|[[:human genes:t:tefm|TEFM]]|0.403|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 25/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|4/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 731
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL13 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>