MRPL22 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL22
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29093|29093]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWU5|Q9NWU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|large ribosomal subunit|
|mitochondrial large ribosomal subunit|
|ribosome assembly|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.8|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.79|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.71|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.85|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.86|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.86|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:q:qrsl1|QRSL1]]|0.56|
|[[:human genes:d:dap3|DAP3]]|0.558|
|[[:human genes:m:mrpl47|MRPL47]]|0.541|
|[[:human genes:f:ftsj2|FTSJ2]]|0.527|
|[[:human genes:m:mrps16|MRPS16]]|0.525|
|[[:human genes:p:pars2|PARS2]]|0.518|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.512|
|[[:human genes:m:mrpl21|MRPL21]]|0.512|
|[[:human genes:m:mrps34|MRPS34]]|0.512|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.511|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.511|
|[[:human genes:m:mrps6|MRPS6]]|0.505|
|[[:human genes:m:mrps25|MRPS25]]|0.5|
|[[:human genes:n:ndufb11|NDUFB11]]|0.499|
|[[:human genes:m:mrpl23|MRPL23]]|0.498|
|[[:human genes:m:mrps14|MRPS14]]|0.498|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.496|
|[[:human genes:s:selrc1|SELRC1]]|0.496|
|[[:human genes:m:mrps21|MRPS21]]|0.495|
|[[:human genes:g:gfm2|GFM2]]|0.491|
|[[:human genes:p:pet117|PET117]]|0.489|
|[[:human genes:n:ndufa3|NDUFA3]]|0.488|
|[[:human genes:y:yars2|YARS2]]|0.485|
|[[:human genes:m:mrps5|MRPS5]]|0.485|
|[[:human genes:e:eral1|ERAL1]]|0.482|
|[[:human genes:m:mrps10|MRPS10]]|0.481|
|[[:human genes:a:acad9|ACAD9]]|0.48|
|[[:human genes:l:lars2|LARS2]]|0.479|
|[[:human genes:f:fastkd2|FASTKD2]]|0.479|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.477|
|[[:human genes:f:fastkd5|FASTKD5]]|0.476|
|[[:human genes:c:c12orf65|C12orf65]]|0.475|
|[[:human genes:c:coa3|COA3]]|0.474|
|[[:human genes:m:mrpl4|MRPL4]]|0.474|
|[[:human genes:s:ssbp1|SSBP1]]|0.473|
|[[:human genes:r:rpusd4|RPUSD4]]|0.469|
|[[:human genes:e:ears2|EARS2]]|0.468|
|[[:human genes:s:sars2|SARS2]]|0.468|
|[[:human genes:n:ndufa1|NDUFA1]]|0.467|
|[[:human genes:m:mrps23|MRPS23]]|0.467|
|[[:human genes:d:dars2|DARS2]]|0.466|
|[[:human genes:n:ndufa2|NDUFA2]]|0.465|
|[[:human genes:n:nars2|NARS2]]|0.465|
|[[:human genes:m:mrps9|MRPS9]]|0.464|
|[[:human genes:m:mcat|MCAT]]|0.463|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.46|
|[[:human genes:n:ndufv1|NDUFV1]]|0.457|
|[[:human genes:m:mrp63|MRP63]]|0.455|
|[[:human genes:p:polrmt|POLRMT]]|0.452|
|[[:human genes:p:ptcd3|PTCD3]]|0.452|
|[[:human genes:c:coq2|COQ2]]|0.45|
|[[:human genes:p:pet112|PET112]]|0.449|
|[[:human genes:v:vars2|VARS2]]|0.448|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.446|
|[[:human genes:s:slc25a26|SLC25A26]]|0.446|
|[[:human genes:w:wars2|WARS2]]|0.446|
|[[:human genes:t:tars2|TARS2]]|0.446|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.445|
|[[:human genes:m:mtg1|MTG1]]|0.444|
|[[:human genes:a:aifm1|AIFM1]]|0.444|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.44|
|[[:human genes:g:grsf1|GRSF1]]|0.44|
|[[:human genes:h:higd2a|HIGD2A]]|0.435|
|[[:human genes:c:chchd1|CHCHD1]]|0.435|
|[[:human genes:m:mrpl15|MRPL15]]|0.432|
|[[:human genes:w:wbscr16|WBSCR16]]|0.432|
|[[:human genes:l:lrpprc|LRPPRC]]|0.431|
|[[:human genes:m:mrpl45|MRPL45]]|0.43|
|[[:human genes:m:mrps26|MRPS26]]|0.429|
|[[:human genes:a:atp5sl|ATP5SL]]|0.429|
|[[:human genes:s:sco2|SCO2]]|0.429|
|[[:human genes:m:mrpl3|MRPL3]]|0.427|
|[[:human genes:m:mterfd2|MTERFD2]]|0.426|
|[[:human genes:g:gfm1|GFM1]]|0.425|
|[[:human genes:m:mars2|MARS2]]|0.424|
|[[:human genes:m:mrpl44|MRPL44]]|0.424|
|[[:human genes:m:malsu1|MALSU1]]|0.423|
|[[:human genes:d:ddx28|DDX28]]|0.423|
|[[:human genes:m:mrps22|MRPS22]]|0.423|
|[[:human genes:m:mettl17|METTL17]]|0.421|
|[[:human genes:r:rmnd1|RMND1]]|0.421|
|[[:human genes:p:prepl|PREPL]]|0.421|
|[[:human genes:r:rbfa|RBFA]]|0.42|
|[[:human genes:p:pnpt1|PNPT1]]|0.42|
|[[:human genes:n:ndufb5|NDUFB5]]|0.415|
|[[:human genes:p:pdss1|PDSS1]]|0.415|
|[[:human genes:t:trub2|TRUB2]]|0.414|
|[[:human genes:t:timm8b|TIMM8B]]|0.413|
|[[:human genes:m:mrpl53|MRPL53]]|0.413|
|[[:human genes:r:rpusd3|RPUSD3]]|0.411|
|[[:human genes:b:bcs1l|BCS1L]]|0.411|
|[[:human genes:m:mrps18a|MRPS18A]]|0.411|
|[[:human genes:g:gatc|GATC]]|0.41|
|[[:human genes:t:tomm20|TOMM20]]|0.41|
|[[:human genes:c:cars2|CARS2]]|0.409|
|[[:human genes:m:mrpl43|MRPL43]]|0.409|
|[[:human genes:r:rars2|RARS2]]|0.409|
|[[:human genes:c:cox16|COX16]]|0.408|
|[[:human genes:m:mrps11|MRPS11]]|0.408|
|[[:human genes:m:mtg2|MTG2]]|0.407|
|[[:human genes:m:mrps7|MRPS7]]|0.406|
|[[:human genes:g:glrx5|GLRX5]]|0.406|
|[[:human genes:i:iba57|IBA57]]|0.405|
|[[:human genes:t:tfb1m|TFB1M]]|0.405|
|[[:human genes:n:ndufs2|NDUFS2]]|0.404|
|[[:human genes:n:ndufb3|NDUFB3]]|0.403|
|[[:human genes:m:mrpl12|MRPL12]]|0.402|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.402|
|[[:human genes:h:hars2|HARS2]]|0.402|
|[[:human genes:n:ndufc2|NDUFC2]]|0.401|
|[[:human genes:m:mto1|MTO1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1949
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL22 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>