MRPL28 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL28 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL28
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L28
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10573|10573]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13084|Q13084]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL28&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL28|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604853|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.77|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.9|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.503|
|[[:human genes:p:pet117|PET117]]|0.498|
|[[:human genes:g:gfm1|GFM1]]|0.496|
|[[:human genes:t:tfb2m|TFB2M]]|0.487|
|[[:human genes:q:qrsl1|QRSL1]]|0.477|
|[[:human genes:n:nars2|NARS2]]|0.475|
|[[:human genes:l:lars2|LARS2]]|0.473|
|[[:human genes:e:eral1|ERAL1]]|0.468|
|[[:human genes:r:rpusd3|RPUSD3]]|0.468|
|[[:human genes:t:tfb1m|TFB1M]]|0.467|
|[[:human genes:v:vars2|VARS2]]|0.463|
|[[:human genes:n:ndufb10|NDUFB10]]|0.46|
|[[:human genes:m:mrpl3|MRPL3]]|0.459|
|[[:human genes:r:rars2|RARS2]]|0.457|
|[[:human genes:g:grsf1|GRSF1]]|0.456|
|[[:human genes:m:mrpl45|MRPL45]]|0.455|
|[[:human genes:m:mrps34|MRPS34]]|0.455|
|[[:human genes:m:mrps35|MRPS35]]|0.453|
|[[:human genes:m:mrps25|MRPS25]]|0.452|
|[[:human genes:m:mrps21|MRPS21]]|0.449|
|[[:human genes:m:mrp63|MRP63]]|0.449|
|[[:human genes:n:ndufb11|NDUFB11]]|0.447|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.447|
|[[:human genes:m:mrps18a|MRPS18A]]|0.445|
|[[:human genes:m:mrps22|MRPS22]]|0.443|
|[[:human genes:m:mars2|MARS2]]|0.441|
|[[:human genes:m:malsu1|MALSU1]]|0.439|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.439|
|[[:human genes:c:cars2|CARS2]]|0.436|
|[[:human genes:m:mrps6|MRPS6]]|0.435|
|[[:human genes:f:fastkd2|FASTKD2]]|0.433|
|[[:human genes:m:mrpl35|MRPL35]]|0.433|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.427|
|[[:human genes:d:dars2|DARS2]]|0.426|
|[[:human genes:m:mrps27|MRPS27]]|0.424|
|[[:human genes:h:hars2|HARS2]]|0.424|
|[[:human genes:c:coa3|COA3]]|0.423|
|[[:human genes:m:mrpl23|MRPL23]]|0.423|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.422|
|[[:human genes:p:pars2|PARS2]]|0.422|
|[[:human genes:m:mrps16|MRPS16]]|0.42|
|[[:human genes:p:polrmt|POLRMT]]|0.418|
|[[:human genes:w:wars2|WARS2]]|0.418|
|[[:human genes:a:aars2|AARS2]]|0.418|
|[[:human genes:p:pet112|PET112]]|0.418|
|[[:human genes:m:mrpl53|MRPL53]]|0.417|
|[[:human genes:n:ndufa3|NDUFA3]]|0.417|
|[[:human genes:f:ftsj2|FTSJ2]]|0.417|
|[[:human genes:m:mrpl21|MRPL21]]|0.415|
|[[:human genes:a:acad9|ACAD9]]|0.414|
|[[:human genes:m:mrpl33|MRPL33]]|0.413|
|[[:human genes:m:mrps26|MRPS26]]|0.408|
|[[:human genes:m:mrpl17|MRPL17]]|0.407|
|[[:human genes:p:prepl|PREPL]]|0.407|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.406|
|[[:human genes:s:selrc1|SELRC1]]|0.405|
|[[:human genes:m:mrpl18|MRPL18]]|0.405|
|[[:human genes:m:mrps7|MRPS7]]|0.403|
|[[:human genes:m:mrpl4|MRPL4]]|0.402|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.401|
|[[:human genes:m:mrps14|MRPS14]]|0.401|
|[[:human genes:t:tfam|TFAM]]|0.4|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 96
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL28 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>