MRPL2 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL2
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51069|51069]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T653|Q5T653]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611822|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L2|
|Ribosomal L2 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.71|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.71|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.76|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.79|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.81|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.85|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.515|
|[[:human genes:m:mrpl23|MRPL23]]|0.512|
|[[:human genes:p:pars2|PARS2]]|0.504|
|[[:human genes:p:pet117|PET117]]|0.497|
|[[:human genes:t:tars2|TARS2]]|0.493|
|[[:human genes:s:selrc1|SELRC1]]|0.485|
|[[:human genes:m:mrps2|MRPS2]]|0.482|
|[[:human genes:m:mtpap|MTPAP]]|0.481|
|[[:human genes:a:aars2|AARS2]]|0.479|
|[[:human genes:n:ndufb11|NDUFB11]]|0.479|
|[[:human genes:y:yars2|YARS2]]|0.478|
|[[:human genes:m:mtg2|MTG2]]|0.474|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.472|
|[[:human genes:m:mrps35|MRPS35]]|0.469|
|[[:human genes:m:mettl17|METTL17]]|0.467|
|[[:human genes:s:sco2|SCO2]]|0.466|
|[[:human genes:r:rpusd4|RPUSD4]]|0.464|
|[[:human genes:p:pet112|PET112]]|0.464|
|[[:human genes:m:mrps34|MRPS34]]|0.464|
|[[:human genes:m:mrps6|MRPS6]]|0.463|
|[[:human genes:c:coa3|COA3]]|0.462|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.462|
|[[:human genes:r:rbfa|RBFA]]|0.462|
|[[:human genes:m:mrpl12|MRPL12]]|0.461|
|[[:human genes:f:fastkd5|FASTKD5]]|0.458|
|[[:human genes:m:mrps21|MRPS21]]|0.458|
|[[:human genes:m:mrps12|MRPS12]]|0.453|
|[[:human genes:g:gfm2|GFM2]]|0.453|
|[[:human genes:m:mrpl3|MRPL3]]|0.451|
|[[:human genes:c:coa6|COA6]]|0.45|
|[[:human genes:m:mrpl18|MRPL18]]|0.449|
|[[:human genes:d:dap3|DAP3]]|0.446|
|[[:human genes:m:mrps26|MRPS26]]|0.445|
|[[:human genes:f:fars2|FARS2]]|0.444|
|[[:human genes:p:polg2|POLG2]]|0.444|
|[[:human genes:m:mrpl45|MRPL45]]|0.443|
|[[:human genes:m:mrps25|MRPS25]]|0.44|
|[[:human genes:m:mrpl21|MRPL21]]|0.433|
|[[:human genes:m:mrpl53|MRPL53]]|0.43|
|[[:human genes:f:fastkd2|FASTKD2]]|0.429|
|[[:human genes:m:mrps24|MRPS24]]|0.427|
|[[:human genes:m:mars2|MARS2]]|0.427|
|[[:human genes:m:mrps9|MRPS9]]|0.426|
|[[:human genes:m:mrpl47|MRPL47]]|0.425|
|[[:human genes:n:ndufs2|NDUFS2]]|0.425|
|[[:human genes:m:mrps5|MRPS5]]|0.425|
|[[:human genes:c:cox11|COX11]]|0.421|
|[[:human genes:m:mrpl20|MRPL20]]|0.417|
|[[:human genes:a:acad9|ACAD9]]|0.417|
|[[:human genes:g:gfm1|GFM1]]|0.416|
|[[:human genes:i:ict1|ICT1]]|0.416|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.415|
|[[:human genes:m:malsu1|MALSU1]]|0.415|
|[[:human genes:l:lars2|LARS2]]|0.414|
|[[:human genes:d:dhx30|DHX30]]|0.413|
|[[:human genes:v:vars2|VARS2]]|0.413|
|[[:human genes:h:hars2|HARS2]]|0.413|
|[[:human genes:g:gatc|GATC]]|0.412|
|[[:human genes:e:ears2|EARS2]]|0.41|
|[[:human genes:d:ddx28|DDX28]]|0.41|
|[[:human genes:m:mrpl4|MRPL4]]|0.409|
|[[:human genes:q:qrsl1|QRSL1]]|0.408|
|[[:human genes:m:mrps27|MRPS27]]|0.408|
|[[:human genes:m:mrpl55|MRPL55]]|0.407|
|[[:human genes:c:cox16|COX16]]|0.405|
|[[:human genes:n:ndufb6|NDUFB6]]|0.405|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.404|
|[[:human genes:m:mtg1|MTG1]]|0.404|
|[[:human genes:m:mrpl15|MRPL15]]|0.401|
|[[:human genes:t:trub2|TRUB2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 25/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL2 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>