MRPL33 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL33
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9553|9553]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75394|O75394]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610059|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L33|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.2|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2.19|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.76|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.7|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.73|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.73|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.83|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.86|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.92|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.1|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.1|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.12|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.13|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.23|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.23|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.36|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.58|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl47|MRPL47]]|0.587|
|[[:human genes:v:vars2|VARS2]]|0.571|
|[[:human genes:d:dap3|DAP3]]|0.57|
|[[:human genes:y:yars2|YARS2]]|0.568|
|[[:human genes:m:mrpl21|MRPL21]]|0.561|
|[[:human genes:m:mrps14|MRPS14]]|0.561|
|[[:human genes:m:mrps18a|MRPS18A]]|0.56|
|[[:human genes:m:mrp63|MRP63]]|0.543|
|[[:human genes:m:mrps34|MRPS34]]|0.543|
|[[:human genes:m:mrpl23|MRPL23]]|0.542|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.53|
|[[:human genes:m:mrps6|MRPS6]]|0.529|
|[[:human genes:m:mrps26|MRPS26]]|0.526|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.526|
|[[:human genes:m:mrps21|MRPS21]]|0.523|
|[[:human genes:m:mrps16|MRPS16]]|0.523|
|[[:human genes:m:mrps9|MRPS9]]|0.519|
|[[:human genes:t:tfam|TFAM]]|0.517|
|[[:human genes:d:dars2|DARS2]]|0.515|
|[[:human genes:q:qrsl1|QRSL1]]|0.515|
|[[:human genes:m:mrpl39|MRPL39]]|0.51|
|[[:human genes:n:nars2|NARS2]]|0.506|
|[[:human genes:t:trub2|TRUB2]]|0.503|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.502|
|[[:human genes:m:mrpl3|MRPL3]]|0.501|
|[[:human genes:c:coa5|COA5]]|0.501|
|[[:human genes:f:fars2|FARS2]]|0.499|
|[[:human genes:m:mrps12|MRPS12]]|0.495|
|[[:human genes:s:sars2|SARS2]]|0.493|
|[[:human genes:c:cox16|COX16]]|0.491|
|[[:human genes:r:rars2|RARS2]]|0.486|
|[[:human genes:m:mars2|MARS2]]|0.484|
|[[:human genes:g:gfm1|GFM1]]|0.483|
|[[:human genes:h:hars2|HARS2]]|0.479|
|[[:human genes:m:mrps5|MRPS5]]|0.478|
|[[:human genes:m:mrpl53|MRPL53]]|0.477|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.475|
|[[:human genes:l:lars2|LARS2]]|0.473|
|[[:human genes:m:mrpl18|MRPL18]]|0.472|
|[[:human genes:m:mrps25|MRPS25]]|0.471|
|[[:human genes:r:rpusd4|RPUSD4]]|0.47|
|[[:human genes:t:tomm20|TOMM20]]|0.469|
|[[:human genes:p:pet112|PET112]]|0.468|
|[[:human genes:s:slc25a26|SLC25A26]]|0.468|
|[[:human genes:t:tars2|TARS2]]|0.468|
|[[:human genes:p:ptcd3|PTCD3]]|0.466|
|[[:human genes:t:tfb2m|TFB2M]]|0.466|
|[[:human genes:s:selrc1|SELRC1]]|0.464|
|[[:human genes:c:coa3|COA3]]|0.462|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.462|
|[[:human genes:m:mrpl44|MRPL44]]|0.459|
|[[:human genes:m:mrps23|MRPS23]]|0.459|
|[[:human genes:m:mrpl45|MRPL45]]|0.459|
|[[:human genes:m:mrpl36|MRPL36]]|0.455|
|[[:human genes:n:ndufa3|NDUFA3]]|0.454|
|[[:human genes:r:rbfa|RBFA]]|0.453|
|[[:human genes:c:cox7b|COX7B]]|0.452|
|[[:human genes:p:pnpt1|PNPT1]]|0.451|
|[[:human genes:m:mrps22|MRPS22]]|0.45|
|[[:human genes:m:mrpl42|MRPL42]]|0.448|
|[[:human genes:m:mrps7|MRPS7]]|0.447|
|[[:human genes:e:ears2|EARS2]]|0.446|
|[[:human genes:m:mtpap|MTPAP]]|0.445|
|[[:human genes:h:higd2a|HIGD2A]]|0.445|
|[[:human genes:m:mrpl15|MRPL15]]|0.445|
|[[:human genes:s:sco2|SCO2]]|0.443|
|[[:human genes:m:mrps2|MRPS2]]|0.442|
|[[:human genes:a:aars2|AARS2]]|0.439|
|[[:human genes:c:c10orf2|C10orf2]]|0.439|
|[[:human genes:m:mrpl41|MRPL41]]|0.438|
|[[:human genes:m:mrpl12|MRPL12]]|0.438|
|[[:human genes:t:tefm|TEFM]]|0.433|
|[[:human genes:t:tufm|TUFM]]|0.433|
|[[:human genes:n:ndufb9|NDUFB9]]|0.431|
|[[:human genes:p:pars2|PARS2]]|0.431|
|[[:human genes:f:ftsj2|FTSJ2]]|0.43|
|[[:human genes:f:fastkd5|FASTKD5]]|0.43|
|[[:human genes:e:elac2|ELAC2]]|0.426|
|[[:human genes:m:mrpl4|MRPL4]]|0.423|
|[[:human genes:b:bcs1l|BCS1L]]|0.422|
|[[:human genes:c:cox6b1|COX6B1]]|0.42|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.417|
|[[:human genes:n:ndufb3|NDUFB3]]|0.415|
|[[:human genes:m:mtg2|MTG2]]|0.415|
|[[:human genes:c:cox6c|COX6C]]|0.414|
|[[:human genes:m:mrpl28|MRPL28]]|0.413|
|[[:human genes:p:pet117|PET117]]|0.411|
|[[:human genes:l:lrpprc|LRPPRC]]|0.411|
|[[:human genes:n:ndufb11|NDUFB11]]|0.409|
|[[:human genes:u:uqcr10|UQCR10]]|0.409|
|[[:human genes:c:cox15|COX15]]|0.407|
|[[:human genes:a:aifm1|AIFM1]]|0.406|
|[[:human genes:g:gatc|GATC]]|0.405|
|[[:human genes:m:mrps24|MRPS24]]|0.405|
|[[:human genes:m:mterfd1|MTERFD1]]|0.405|
|[[:human genes:m:mrpl13|MRPL13]]|0.404|
|[[:human genes:n:ndufc2|NDUFC2]]|0.404|
|[[:human genes:m:mrps17|MRPS17]]|0.4|
|[[:human genes:n:ndufa1|NDUFA1]]|0.4|
|[[:human genes:t:tfb1m|TFB1M]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 477/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|18/28|
|bone|14/26|
|breast|24/33|
|central nervous system|30/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|7/21|
|liver|14/20|
|lung|58/75|
|lymphocyte|11/16|
|ovary|15/26|
|pancreas|11/24|
|peripheral nervous system|10/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 230
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL33 Expression in NALM6 Cells: 3.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>