MRPL39 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL39
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L39
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54148|54148]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYK5|Q9NYK5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|nucleotide binding|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.79|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.73|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.93|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.94|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.3|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dap3|DAP3]]|0.595|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.553|
|[[:human genes:m:mrpl21|MRPL21]]|0.541|
|[[:human genes:m:mrps16|MRPS16]]|0.527|
|[[:human genes:m:mrp63|MRP63]]|0.525|
|[[:human genes:m:mrps34|MRPS34]]|0.525|
|[[:human genes:n:nars2|NARS2]]|0.524|
|[[:human genes:m:mrpl23|MRPL23]]|0.523|
|[[:human genes:m:mrps26|MRPS26]]|0.521|
|[[:human genes:d:dars2|DARS2]]|0.519|
|[[:human genes:m:mrpl20|MRPL20]]|0.515|
|[[:human genes:l:lars2|LARS2]]|0.511|
|[[:human genes:m:mrpl33|MRPL33]]|0.51|
|[[:human genes:m:mrpl47|MRPL47]]|0.51|
|[[:human genes:m:mrpl53|MRPL53]]|0.505|
|[[:human genes:v:vars2|VARS2]]|0.504|
|[[:human genes:m:mrps2|MRPS2]]|0.503|
|[[:human genes:m:mrps14|MRPS14]]|0.501|
|[[:human genes:m:mrps6|MRPS6]]|0.501|
|[[:human genes:g:gfm1|GFM1]]|0.501|
|[[:human genes:p:pars2|PARS2]]|0.499|
|[[:human genes:f:ftsj2|FTSJ2]]|0.496|
|[[:human genes:t:tars2|TARS2]]|0.495|
|[[:human genes:r:rpusd4|RPUSD4]]|0.494|
|[[:human genes:e:ears2|EARS2]]|0.486|
|[[:human genes:m:mrps12|MRPS12]]|0.485|
|[[:human genes:a:aars2|AARS2]]|0.483|
|[[:human genes:y:yars2|YARS2]]|0.482|
|[[:human genes:q:qrsl1|QRSL1]]|0.48|
|[[:human genes:m:mrpl45|MRPL45]]|0.48|
|[[:human genes:m:mars2|MARS2]]|0.479|
|[[:human genes:m:mrps23|MRPS23]]|0.475|
|[[:human genes:r:rpusd3|RPUSD3]]|0.473|
|[[:human genes:t:trub2|TRUB2]]|0.471|
|[[:human genes:m:mrpl3|MRPL3]]|0.47|
|[[:human genes:p:pnpt1|PNPT1]]|0.469|
|[[:human genes:p:pet117|PET117]]|0.469|
|[[:human genes:m:mrpl49|MRPL49]]|0.467|
|[[:human genes:s:sco2|SCO2]]|0.463|
|[[:human genes:m:mrps11|MRPS11]]|0.459|
|[[:human genes:m:mrpl4|MRPL4]]|0.454|
|[[:human genes:h:hars2|HARS2]]|0.454|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.452|
|[[:human genes:m:mrps25|MRPS25]]|0.452|
|[[:human genes:t:tefm|TEFM]]|0.451|
|[[:human genes:m:mrps21|MRPS21]]|0.45|
|[[:human genes:c:cox11|COX11]]|0.449|
|[[:human genes:t:tomm20|TOMM20]]|0.448|
|[[:human genes:s:sars2|SARS2]]|0.446|
|[[:human genes:m:mrps22|MRPS22]]|0.446|
|[[:human genes:g:gfm2|GFM2]]|0.445|
|[[:human genes:e:eral1|ERAL1]]|0.445|
|[[:human genes:m:mrps9|MRPS9]]|0.444|
|[[:human genes:p:pet112|PET112]]|0.444|
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:m:mterfd1|MTERFD1]]|0.443|
|[[:human genes:w:wbscr16|WBSCR16]]|0.443|
|[[:human genes:c:coa3|COA3]]|0.442|
|[[:human genes:m:mrpl42|MRPL42]]|0.44|
|[[:human genes:m:mrps7|MRPS7]]|0.439|
|[[:human genes:c:cars2|CARS2]]|0.438|
|[[:human genes:m:mrpl36|MRPL36]]|0.436|
|[[:human genes:r:rbfa|RBFA]]|0.434|
|[[:human genes:b:bcs1l|BCS1L]]|0.434|
|[[:human genes:s:selrc1|SELRC1]]|0.434|
|[[:human genes:m:mrps5|MRPS5]]|0.434|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.432|
|[[:human genes:p:polrmt|POLRMT]]|0.432|
|[[:human genes:s:slc25a26|SLC25A26]]|0.432|
|[[:human genes:m:mrpl17|MRPL17]]|0.428|
|[[:human genes:m:mrps18a|MRPS18A]]|0.424|
|[[:human genes:m:mrpl52|MRPL52]]|0.423|
|[[:human genes:f:fars2|FARS2]]|0.422|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.422|
|[[:human genes:t:tufm|TUFM]]|0.422|
|[[:human genes:m:mrps24|MRPS24]]|0.421|
|[[:human genes:t:tfam|TFAM]]|0.418|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.418|
|[[:human genes:p:pdss2|PDSS2]]|0.415|
|[[:human genes:f:fastkd5|FASTKD5]]|0.414|
|[[:human genes:n:ndufb11|NDUFB11]]|0.414|
|[[:human genes:c:coa6|COA6]]|0.413|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.412|
|[[:human genes:m:mrps35|MRPS35]]|0.411|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.41|
|[[:human genes:c:chchd1|CHCHD1]]|0.41|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.41|
|[[:human genes:c:coq2|COQ2]]|0.409|
|[[:human genes:n:ndufa1|NDUFA1]]|0.407|
|[[:human genes:p:ptcd3|PTCD3]]|0.403|
|[[:human genes:s:ssbp1|SSBP1]]|0.402|
|[[:human genes:r:rars2|RARS2]]|0.402|
|[[:human genes:c:cox7b|COX7B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 221/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|5/28|
|bone|7/26|
|breast|14/33|
|central nervous system|13/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|6/21|
|liver|8/20|
|lung|21/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|13/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 574
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL39 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>