MRPL41 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL41 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL41
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L41
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64975|64975]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXM3|Q8IXM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL41&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL41|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611846|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796). {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:16256947, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-L27|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|ribonucleoprotein complex|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|apoptotic process|
|programmed cell death|
|cell death|
|mitochondrion|
|cell cycle|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.13|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.92|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.85|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.77|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.77|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.78|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.83|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.89|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.89|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.91|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.93|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.07|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.1|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.34|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.519|
|[[:human genes:y:yars2|YARS2]]|0.518|
|[[:human genes:n:ndufa3|NDUFA3]]|0.518|
|[[:human genes:m:mrps34|MRPS34]]|0.503|
|[[:human genes:m:mrpl23|MRPL23]]|0.5|
|[[:human genes:m:mrp63|MRP63]]|0.498|
|[[:human genes:m:mrps21|MRPS21]]|0.487|
|[[:human genes:d:dap3|DAP3]]|0.487|
|[[:human genes:r:rpusd4|RPUSD4]]|0.486|
|[[:human genes:m:mrps18a|MRPS18A]]|0.484|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.48|
|[[:human genes:m:mrps5|MRPS5]]|0.479|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.478|
|[[:human genes:m:mrps6|MRPS6]]|0.478|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.478|
|[[:human genes:m:mrpl47|MRPL47]]|0.472|
|[[:human genes:t:tefm|TEFM]]|0.47|
|[[:human genes:n:ndufb11|NDUFB11]]|0.468|
|[[:human genes:m:mtg1|MTG1]]|0.468|
|[[:human genes:s:sars2|SARS2]]|0.466|
|[[:human genes:m:mrps14|MRPS14]]|0.458|
|[[:human genes:c:cox16|COX16]]|0.456|
|[[:human genes:t:tars2|TARS2]]|0.456|
|[[:human genes:t:trub2|TRUB2]]|0.453|
|[[:human genes:m:mrps16|MRPS16]]|0.451|
|[[:human genes:m:mrps26|MRPS26]]|0.45|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.45|
|[[:human genes:n:ndufc2|NDUFC2]]|0.447|
|[[:human genes:d:dars2|DARS2]]|0.446|
|[[:human genes:n:ndufc1|NDUFC1]]|0.444|
|[[:human genes:s:selrc1|SELRC1]]|0.444|
|[[:human genes:m:mrpl12|MRPL12]]|0.44|
|[[:human genes:m:mrpl33|MRPL33]]|0.438|
|[[:human genes:m:mrps25|MRPS25]]|0.435|
|[[:human genes:f:fastkd5|FASTKD5]]|0.434|
|[[:human genes:m:mrpl53|MRPL53]]|0.433|
|[[:human genes:q:qrsl1|QRSL1]]|0.432|
|[[:human genes:n:ndufa2|NDUFA2]]|0.431|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.428|
|[[:human genes:r:rars2|RARS2]]|0.426|
|[[:human genes:a:atp5a1|ATP5A1]]|0.425|
|[[:human genes:m:mrpl15|MRPL15]]|0.423|
|[[:human genes:n:ndufv1|NDUFV1]]|0.42|
|[[:human genes:m:mrps24|MRPS24]]|0.419|
|[[:human genes:e:ears2|EARS2]]|0.419|
|[[:human genes:p:polrmt|POLRMT]]|0.417|
|[[:human genes:m:mrpl4|MRPL4]]|0.417|
|[[:human genes:p:ptcd3|PTCD3]]|0.414|
|[[:human genes:w:wbscr16|WBSCR16]]|0.41|
|[[:human genes:p:pars2|PARS2]]|0.409|
|[[:human genes:t:tomm20|TOMM20]]|0.409|
|[[:human genes:n:nars2|NARS2]]|0.409|
|[[:human genes:m:mrps11|MRPS11]]|0.408|
|[[:human genes:m:mrpl44|MRPL44]]|0.408|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.407|
|[[:human genes:m:mterfd2|MTERFD2]]|0.405|
|[[:human genes:c:c12orf65|C12orf65]]|0.405|
|[[:human genes:u:uqcr10|UQCR10]]|0.404|
|[[:human genes:m:mtg2|MTG2]]|0.403|
|[[:human genes:g:gatc|GATC]]|0.403|
|[[:human genes:m:mrpl34|MRPL34]]|0.403|
|[[:human genes:n:ndufs7|NDUFS7]]|0.402|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.401|
|[[:human genes:d:ddx28|DDX28]]|0.401|
|[[:human genes:c:chchd1|CHCHD1]]|0.4|
|[[:human genes:r:rbfa|RBFA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 140/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|8/28|
|bone|4/26|
|breast|8/33|
|central nervous system|9/56|
|cervix|2/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|4/21|
|liver|5/20|
|lung|16/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|3/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 265
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL41 Expression in NALM6 Cells: 2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>