MRPL51 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL51 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL51
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L51
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51258|51258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4U2R6|Q4U2R6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL51&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL51|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611855|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-L51|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.77|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.7|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.74|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.76|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.79|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.81|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.09|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps21|MRPS21]]|0.51|
|[[:human genes:m:mrpl45|MRPL45]]|0.509|
|[[:human genes:r:rars2|RARS2]]|0.485|
|[[:human genes:n:nars2|NARS2]]|0.484|
|[[:human genes:m:mrpl47|MRPL47]]|0.477|
|[[:human genes:p:pars2|PARS2]]|0.476|
|[[:human genes:d:dap3|DAP3]]|0.473|
|[[:human genes:s:selrc1|SELRC1]]|0.467|
|[[:human genes:m:mrps12|MRPS12]]|0.466|
|[[:human genes:g:gfm1|GFM1]]|0.464|
|[[:human genes:m:mettl17|METTL17]]|0.463|
|[[:human genes:r:rpusd3|RPUSD3]]|0.459|
|[[:human genes:m:mars2|MARS2]]|0.457|
|[[:human genes:m:mrps6|MRPS6]]|0.452|
|[[:human genes:p:ptcd3|PTCD3]]|0.449|
|[[:human genes:m:mrpl3|MRPL3]]|0.448|
|[[:human genes:w:wbscr16|WBSCR16]]|0.446|
|[[:human genes:e:ears2|EARS2]]|0.446|
|[[:human genes:a:aars2|AARS2]]|0.445|
|[[:human genes:y:yars2|YARS2]]|0.443|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.441|
|[[:human genes:m:mrpl21|MRPL21]]|0.44|
|[[:human genes:m:mrps16|MRPS16]]|0.437|
|[[:human genes:m:mrps7|MRPS7]]|0.435|
|[[:human genes:r:rbfa|RBFA]]|0.435|
|[[:human genes:t:trub2|TRUB2]]|0.432|
|[[:human genes:c:coa3|COA3]]|0.431|
|[[:human genes:p:pnpt1|PNPT1]]|0.427|
|[[:human genes:c:cars2|CARS2]]|0.425|
|[[:human genes:m:mrpl14|MRPL14]]|0.425|
|[[:human genes:m:mrpl42|MRPL42]]|0.421|
|[[:human genes:t:tufm|TUFM]]|0.421|
|[[:human genes:m:mrps14|MRPS14]]|0.416|
|[[:human genes:c:cox16|COX16]]|0.415|
|[[:human genes:m:mrps28|MRPS28]]|0.413|
|[[:human genes:l:lars2|LARS2]]|0.413|
|[[:human genes:c:cox7b|COX7B]]|0.412|
|[[:human genes:m:mrpl20|MRPL20]]|0.412|
|[[:human genes:p:pet117|PET117]]|0.412|
|[[:human genes:p:pet112|PET112]]|0.412|
|[[:human genes:m:mrps5|MRPS5]]|0.411|
|[[:human genes:m:mrps27|MRPS27]]|0.411|
|[[:human genes:m:mrps10|MRPS10]]|0.411|
|[[:human genes:h:hars2|HARS2]]|0.409|
|[[:human genes:c:cox17|COX17]]|0.407|
|[[:human genes:r:rpusd4|RPUSD4]]|0.407|
|[[:human genes:q:qrsl1|QRSL1]]|0.407|
|[[:human genes:m:mrpl23|MRPL23]]|0.406|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.405|
|[[:human genes:f:fastkd5|FASTKD5]]|0.403|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.402|
|[[:human genes:m:mrps34|MRPS34]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 781
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL51 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>