MRPS12 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS12
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6183|6183]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15235|O15235]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603021|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial small ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.72|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.77|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.84|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.88|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.98|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl23|MRPL23]]|0.611|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.609|
|[[:human genes:y:yars2|YARS2]]|0.607|
|[[:human genes:m:mrps5|MRPS5]]|0.605|
|[[:human genes:m:mrpl53|MRPL53]]|0.602|
|[[:human genes:m:mrps26|MRPS26]]|0.6|
|[[:human genes:m:mrpl21|MRPL21]]|0.599|
|[[:human genes:t:trub2|TRUB2]]|0.598|
|[[:human genes:v:vars2|VARS2]]|0.596|
|[[:human genes:q:qrsl1|QRSL1]]|0.594|
|[[:human genes:m:mrps34|MRPS34]]|0.593|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.591|
|[[:human genes:p:pet112|PET112]]|0.59|
|[[:human genes:m:mrps21|MRPS21]]|0.589|
|[[:human genes:m:mrps16|MRPS16]]|0.586|
|[[:human genes:m:mars2|MARS2]]|0.578|
|[[:human genes:d:dap3|DAP3]]|0.576|
|[[:human genes:m:mtpap|MTPAP]]|0.57|
|[[:human genes:m:mrpl47|MRPL47]]|0.57|
|[[:human genes:m:mrpl18|MRPL18]]|0.569|
|[[:human genes:m:mrp63|MRP63]]|0.566|
|[[:human genes:d:dars2|DARS2]]|0.565|
|[[:human genes:n:nars2|NARS2]]|0.562|
|[[:human genes:m:mrpl3|MRPL3]]|0.562|
|[[:human genes:f:fars2|FARS2]]|0.561|
|[[:human genes:m:mrps2|MRPS2]]|0.557|
|[[:human genes:f:ftsj2|FTSJ2]]|0.557|
|[[:human genes:c:coa3|COA3]]|0.556|
|[[:human genes:p:pars2|PARS2]]|0.555|
|[[:human genes:s:selrc1|SELRC1]]|0.554|
|[[:human genes:a:aars2|AARS2]]|0.553|
|[[:human genes:m:mrps6|MRPS6]]|0.551|
|[[:human genes:m:mrps14|MRPS14]]|0.549|
|[[:human genes:r:rpusd4|RPUSD4]]|0.547|
|[[:human genes:t:tars2|TARS2]]|0.547|
|[[:human genes:w:wbscr16|WBSCR16]]|0.545|
|[[:human genes:m:mrps25|MRPS25]]|0.542|
|[[:human genes:m:mettl17|METTL17]]|0.54|
|[[:human genes:m:mrps18a|MRPS18A]]|0.539|
|[[:human genes:g:gfm1|GFM1]]|0.539|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.537|
|[[:human genes:m:mtg2|MTG2]]|0.535|
|[[:human genes:m:mrpl55|MRPL55]]|0.531|
|[[:human genes:r:rars2|RARS2]]|0.531|
|[[:human genes:f:fastkd5|FASTKD5]]|0.53|
|[[:human genes:p:pet117|PET117]]|0.529|
|[[:human genes:s:sco2|SCO2]]|0.525|
|[[:human genes:c:cox16|COX16]]|0.524|
|[[:human genes:m:mrps24|MRPS24]]|0.524|
|[[:human genes:e:ears2|EARS2]]|0.524|
|[[:human genes:t:tomm20|TOMM20]]|0.523|
|[[:human genes:t:tefm|TEFM]]|0.517|
|[[:human genes:n:ndufb11|NDUFB11]]|0.517|
|[[:human genes:m:mrps35|MRPS35]]|0.516|
|[[:human genes:c:coa6|COA6]]|0.511|
|[[:human genes:s:sars2|SARS2]]|0.509|
|[[:human genes:m:mrps9|MRPS9]]|0.508|
|[[:human genes:m:mtg1|MTG1]]|0.508|
|[[:human genes:d:ddx28|DDX28]]|0.506|
|[[:human genes:m:mrps27|MRPS27]]|0.505|
|[[:human genes:l:lars2|LARS2]]|0.502|
|[[:human genes:m:mrpl20|MRPL20]]|0.502|
|[[:human genes:m:mipep|MIPEP]]|0.502|
|[[:human genes:m:mrpl15|MRPL15]]|0.501|
|[[:human genes:r:rpusd3|RPUSD3]]|0.5|
|[[:human genes:r:rbfa|RBFA]]|0.5|
|[[:human genes:n:ndufa3|NDUFA3]]|0.499|
|[[:human genes:g:gfm2|GFM2]]|0.498|
|[[:human genes:c:chchd1|CHCHD1]]|0.496|
|[[:human genes:m:mrpl44|MRPL44]]|0.496|
|[[:human genes:a:aifm1|AIFM1]]|0.496|
|[[:human genes:m:mrpl33|MRPL33]]|0.495|
|[[:human genes:g:gatc|GATC]]|0.494|
|[[:human genes:m:mrpl17|MRPL17]]|0.493|
|[[:human genes:m:mrpl49|MRPL49]]|0.491|
|[[:human genes:h:hars2|HARS2]]|0.491|
|[[:human genes:m:mrpl37|MRPL37]]|0.489|
|[[:human genes:b:bcs1l|BCS1L]]|0.487|
|[[:human genes:c:c10orf2|C10orf2]]|0.487|
|[[:human genes:p:ptcd3|PTCD3]]|0.487|
|[[:human genes:c:cox11|COX11]]|0.486|
|[[:human genes:c:coa5|COA5]]|0.486|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.485|
|[[:human genes:m:mrps22|MRPS22]]|0.485|
|[[:human genes:m:mrpl39|MRPL39]]|0.485|
|[[:human genes:c:cox7b|COX7B]]|0.485|
|[[:human genes:t:tufm|TUFM]]|0.479|
|[[:human genes:s:slc25a26|SLC25A26]]|0.477|
|[[:human genes:m:mterfd2|MTERFD2]]|0.474|
|[[:human genes:m:malsu1|MALSU1]]|0.472|
|[[:human genes:m:mrpl45|MRPL45]]|0.472|
|[[:human genes:c:cox17|COX17]]|0.471|
|[[:human genes:n:ndufa1|NDUFA1]]|0.471|
|[[:human genes:p:pnpt1|PNPT1]]|0.468|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.468|
|[[:human genes:m:mrpl34|MRPL34]]|0.467|
|[[:human genes:m:mrpl36|MRPL36]]|0.467|
|[[:human genes:m:mrpl51|MRPL51]]|0.466|
|[[:human genes:p:pdss1|PDSS1]]|0.465|
|[[:human genes:n:ndufb9|NDUFB9]]|0.465|
|[[:human genes:m:mrpl4|MRPL4]]|0.464|
|[[:human genes:c:cox6b1|COX6B1]]|0.464|
|[[:human genes:h:higd2a|HIGD2A]]|0.463|
|[[:human genes:a:acad9|ACAD9]]|0.463|
|[[:human genes:m:mrpl12|MRPL12]]|0.462|
|[[:human genes:c:cars2|CARS2]]|0.462|
|[[:human genes:i:ict1|ICT1]]|0.461|
|[[:human genes:c:c12orf65|C12orf65]]|0.46|
|[[:human genes:m:mrpl42|MRPL42]]|0.46|
|[[:human genes:n:ndufs2|NDUFS2]]|0.459|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.458|
|[[:human genes:n:ndufa2|NDUFA2]]|0.455|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.453|
|[[:human genes:m:mrpl2|MRPL2]]|0.453|
|[[:human genes:n:ndufb6|NDUFB6]]|0.452|
|[[:human genes:e:eral1|ERAL1]]|0.452|
|[[:human genes:c:coq2|COQ2]]|0.452|
|[[:human genes:n:ndufa11|NDUFA11]]|0.449|
|[[:human genes:m:mrps10|MRPS10]]|0.447|
|[[:human genes:i:iba57|IBA57]]|0.446|
|[[:human genes:l:lrpprc|LRPPRC]]|0.445|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.443|
|[[:human genes:n:nsun4|NSUN4]]|0.443|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.443|
|[[:human genes:m:mrpl13|MRPL13]]|0.442|
|[[:human genes:c:clpp|CLPP]]|0.442|
|[[:human genes:c:cox15|COX15]]|0.441|
|[[:human genes:m:mrps7|MRPS7]]|0.441|
|[[:human genes:m:mtif2|MTIF2]]|0.44|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.439|
|[[:human genes:s:slc31a1|SLC31A1]]|0.438|
|[[:human genes:c:cox20|COX20]]|0.438|
|[[:human genes:m:mrpl52|MRPL52]]|0.437|
|[[:human genes:u:uqcc2|UQCC2]]|0.437|
|[[:human genes:c:cox7c|COX7C]]|0.434|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.434|
|[[:human genes:n:ndufc2|NDUFC2]]|0.432|
|[[:human genes:c:coq3|COQ3]]|0.432|
|[[:human genes:g:glrx5|GLRX5]]|0.43|
|[[:human genes:m:mrpl43|MRPL43]]|0.426|
|[[:human genes:m:mrps33|MRPS33]]|0.426|
|[[:human genes:p:polrmt|POLRMT]]|0.425|
|[[:human genes:u:uqcr10|UQCR10]]|0.422|
|[[:human genes:n:ndufv1|NDUFV1]]|0.422|
|[[:human genes:t:tfam|TFAM]]|0.421|
|[[:human genes:m:mcat|MCAT]]|0.421|
|[[:human genes:p:polg2|POLG2]]|0.42|
|[[:human genes:e:ecsit|ECSIT]]|0.419|
|[[:human genes:t:tfb2m|TFB2M]]|0.418|
|[[:human genes:g:grsf1|GRSF1]]|0.418|
|[[:human genes:c:cox6c|COX6C]]|0.418|
|[[:human genes:f:fastkd2|FASTKD2]]|0.417|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.414|
|[[:human genes:t:tmem261|TMEM261]]|0.413|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.413|
|[[:human genes:m:mrpl11|MRPL11]]|0.41|
|[[:human genes:m:mterfd1|MTERFD1]]|0.408|
|[[:human genes:n:ndufc1|NDUFC1]]|0.406|
|[[:human genes:n:nubpl|NUBPL]]|0.406|
|[[:human genes:m:mrpl24|MRPL24]]|0.406|
|[[:human genes:w:wars2|WARS2]]|0.404|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.403|
|[[:human genes:m:mrpl19|MRPL19]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 97/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|2/28|
|bone|6/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|1/21|
|liver|5/20|
|lung|13/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 839
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS12 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>