MRPS2 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS2
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51116|51116]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y399|Q9Y399]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611971|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome assembly|
|mitochondrial small ribosomal subunit|
|ribosome assembly|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.94|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.7|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.74|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.8|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.83|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.89|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.9|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.12|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.29|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.693|
|[[:human genes:t:tars2|TARS2]]|0.642|
|[[:human genes:m:mrps34|MRPS34]]|0.64|
|[[:human genes:s:sars2|SARS2]]|0.635|
|[[:human genes:m:mrpl23|MRPL23]]|0.63|
|[[:human genes:m:mrps9|MRPS9]]|0.625|
|[[:human genes:f:fastkd5|FASTKD5]]|0.617|
|[[:human genes:s:sco2|SCO2]]|0.614|
|[[:human genes:d:dars2|DARS2]]|0.609|
|[[:human genes:m:mrpl21|MRPL21]]|0.607|
|[[:human genes:d:dap3|DAP3]]|0.607|
|[[:human genes:m:mrps16|MRPS16]]|0.606|
|[[:human genes:m:mrps14|MRPS14]]|0.599|
|[[:human genes:v:vars2|VARS2]]|0.597|
|[[:human genes:m:mrps6|MRPS6]]|0.596|
|[[:human genes:c:cox16|COX16]]|0.595|
|[[:human genes:m:mrps5|MRPS5]]|0.592|
|[[:human genes:p:pars2|PARS2]]|0.591|
|[[:human genes:m:mrpl53|MRPL53]]|0.59|
|[[:human genes:s:selrc1|SELRC1]]|0.586|
|[[:human genes:r:rpusd4|RPUSD4]]|0.585|
|[[:human genes:g:gfm1|GFM1]]|0.582|
|[[:human genes:y:yars2|YARS2]]|0.581|
|[[:human genes:f:fars2|FARS2]]|0.571|
|[[:human genes:e:ears2|EARS2]]|0.571|
|[[:human genes:m:mrps21|MRPS21]]|0.568|
|[[:human genes:m:mrpl47|MRPL47]]|0.567|
|[[:human genes:m:mars2|MARS2]]|0.565|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.563|
|[[:human genes:q:qrsl1|QRSL1]]|0.562|
|[[:human genes:m:mrps18a|MRPS18A]]|0.561|
|[[:human genes:m:mrps26|MRPS26]]|0.56|
|[[:human genes:m:mrps12|MRPS12]]|0.557|
|[[:human genes:m:mrp63|MRP63]]|0.557|
|[[:human genes:c:coa3|COA3]]|0.557|
|[[:human genes:m:mtg2|MTG2]]|0.554|
|[[:human genes:b:bcs1l|BCS1L]]|0.552|
|[[:human genes:m:mrps24|MRPS24]]|0.548|
|[[:human genes:t:tufm|TUFM]]|0.547|
|[[:human genes:h:hars2|HARS2]]|0.546|
|[[:human genes:c:c10orf2|C10orf2]]|0.545|
|[[:human genes:m:mrpl55|MRPL55]]|0.543|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.543|
|[[:human genes:n:nars2|NARS2]]|0.538|
|[[:human genes:m:mtpap|MTPAP]]|0.538|
|[[:human genes:m:mrpl20|MRPL20]]|0.537|
|[[:human genes:c:coa5|COA5]]|0.534|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.529|
|[[:human genes:c:cox17|COX17]]|0.528|
|[[:human genes:m:mrpl12|MRPL12]]|0.527|
|[[:human genes:s:slc25a26|SLC25A26]]|0.526|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.524|
|[[:human genes:c:coa6|COA6]]|0.523|
|[[:human genes:m:mrps25|MRPS25]]|0.52|
|[[:human genes:g:gfm2|GFM2]]|0.519|
|[[:human genes:m:mrps33|MRPS33]]|0.519|
|[[:human genes:n:ndufb11|NDUFB11]]|0.517|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.514|
|[[:human genes:u:uqcr10|UQCR10]]|0.512|
|[[:human genes:a:aars2|AARS2]]|0.506|
|[[:human genes:c:chchd4|CHCHD4]]|0.503|
|[[:human genes:g:gatc|GATC]]|0.503|
|[[:human genes:m:mrpl39|MRPL39]]|0.503|
|[[:human genes:r:rars2|RARS2]]|0.502|
|[[:human genes:a:atp5c1|ATP5C1]]|0.502|
|[[:human genes:m:mrps22|MRPS22]]|0.502|
|[[:human genes:p:polrmt|POLRMT]]|0.502|
|[[:human genes:m:mrpl3|MRPL3]]|0.502|
|[[:human genes:p:pgm3|PGM3]]|0.499|
|[[:human genes:m:mrpl15|MRPL15]]|0.498|
|[[:human genes:t:tefm|TEFM]]|0.498|
|[[:human genes:m:mrpl34|MRPL34]]|0.497|
|[[:human genes:w:wbscr16|WBSCR16]]|0.493|
|[[:human genes:e:elac2|ELAC2]]|0.493|
|[[:human genes:n:ndufa3|NDUFA3]]|0.492|
|[[:human genes:t:trub2|TRUB2]]|0.49|
|[[:human genes:r:rbfa|RBFA]]|0.489|
|[[:human genes:m:mrpl36|MRPL36]]|0.488|
|[[:human genes:c:cox5a|COX5A]]|0.488|
|[[:human genes:c:cox11|COX11]]|0.486|
|[[:human genes:t:tmem242|TMEM242]]|0.485|
|[[:human genes:t:triap1|TRIAP1]]|0.485|
|[[:human genes:c:cox7b|COX7B]]|0.483|
|[[:human genes:m:mrpl2|MRPL2]]|0.482|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.481|
|[[:human genes:c:cox6c|COX6C]]|0.479|
|[[:human genes:c:chchd1|CHCHD1]]|0.476|
|[[:human genes:s:slc25a19|SLC25A19]]|0.476|
|[[:human genes:m:mrpl18|MRPL18]]|0.474|
|[[:human genes:l:lars2|LARS2]]|0.474|
|[[:human genes:r:rpia|RPIA]]|0.472|
|[[:human genes:t:tomm20|TOMM20]]|0.467|
|[[:human genes:p:pnpt1|PNPT1]]|0.466|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.464|
|[[:human genes:c:cox6b1|COX6B1]]|0.461|
|[[:human genes:d:dhrsx|DHRSX]]|0.459|
|[[:human genes:i:iba57|IBA57]]|0.458|
|[[:human genes:m:mrps7|MRPS7]]|0.455|
|[[:human genes:m:mrpl44|MRPL44]]|0.455|
|[[:human genes:p:polg2|POLG2]]|0.454|
|[[:human genes:m:mrps11|MRPS11]]|0.454|
|[[:human genes:t:tamm41|TAMM41]]|0.453|
|[[:human genes:t:tfam|TFAM]]|0.452|
|[[:human genes:m:mrpl11|MRPL11]]|0.452|
|[[:human genes:p:pet112|PET112]]|0.451|
|[[:human genes:m:mtg1|MTG1]]|0.45|
|[[:human genes:c:cox15|COX15]]|0.45|
|[[:human genes:c:c12orf65|C12orf65]]|0.449|
|[[:human genes:m:mrps10|MRPS10]]|0.447|
|[[:human genes:d:dhx30|DHX30]]|0.447|
|[[:human genes:t:tpk1|TPK1]]|0.447|
|[[:human genes:m:mrpl45|MRPL45]]|0.446|
|[[:human genes:a:atic|ATIC]]|0.445|
|[[:human genes:m:mrpl27|MRPL27]]|0.445|
|[[:human genes:h:hccs|HCCS]]|0.444|
|[[:human genes:e:ecsit|ECSIT]]|0.444|
|[[:human genes:c:cycs|CYCS]]|0.443|
|[[:human genes:c:c17orf89|C17orf89]]|0.443|
|[[:human genes:m:mrpl33|MRPL33]]|0.442|
|[[:human genes:m:mrpl42|MRPL42]]|0.442|
|[[:human genes:m:mipep|MIPEP]]|0.441|
|[[:human genes:m:mrps35|MRPS35]]|0.439|
|[[:human genes:f:ftsj2|FTSJ2]]|0.438|
|[[:human genes:a:atp5d|ATP5D]]|0.437|
|[[:human genes:p:polg|POLG]]|0.436|
|[[:human genes:p:pdss1|PDSS1]]|0.435|
|[[:human genes:a:aifm1|AIFM1]]|0.434|
|[[:human genes:p:pet100|PET100]]|0.433|
|[[:human genes:u:uap1|UAP1]]|0.433|
|[[:human genes:m:mrpl9|MRPL9]]|0.432|
|[[:human genes:m:mrpl37|MRPL37]]|0.43|
|[[:human genes:n:ndufb6|NDUFB6]]|0.429|
|[[:human genes:p:pet117|PET117]]|0.428|
|[[:human genes:n:ndufb3|NDUFB3]]|0.427|
|[[:human genes:m:mrpl43|MRPL43]]|0.427|
|[[:human genes:n:ndufb5|NDUFB5]]|0.427|
|[[:human genes:p:pmm2|PMM2]]|0.426|
|[[:human genes:l:lsm10|LSM10]]|0.425|
|[[:human genes:m:mrpl32|MRPL32]]|0.425|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.425|
|[[:human genes:d:dnlz|DNLZ]]|0.424|
|[[:human genes:m:mrps23|MRPS23]]|0.421|
|[[:human genes:p:ppcs|PPCS]]|0.421|
|[[:human genes:v:vezt|VEZT]]|0.42|
|[[:human genes:a:alg1|ALG1]]|0.417|
|[[:human genes:u:uqcrq|UQCRQ]]|0.416|
|[[:human genes:f:fh|FH]]|0.415|
|[[:human genes:w:wars2|WARS2]]|0.414|
|[[:human genes:a:atp5b|ATP5B]]|0.412|
|[[:human genes:n:ndufa2|NDUFA2]]|0.409|
|[[:human genes:p:ppa2|PPA2]]|0.409|
|[[:human genes:a:atp5a1|ATP5A1]]|0.409|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.405|
|[[:human genes:t:tomm40|TOMM40]]|0.405|
|[[:human genes:d:dolk|DOLK]]|0.404|
|[[:human genes:s:ssb|SSB]]|0.404|
|[[:human genes:u:uqcrfs1|UQCRFS1]]|0.403|
|[[:human genes:t:trmt61a|TRMT61A]]|0.403|
|[[:human genes:n:ndufa1|NDUFA1]]|0.402|
|[[:human genes:t:thg1l|THG1L]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2331
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS2 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>