MRTO4 [The Human Chemical-Genetic Interaction Map Project]

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======= MRTO4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRTO4
  * **<color #00a2e8>Official Name</color>**: MRT4 homolog, ribosome maturation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51154|51154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKD2|Q9UKD2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRTO4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRTO4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620476|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. {ECO:0000269|PubMed:20083226}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome, large subunit precursor|
|ribosomal large subunit assembly|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|ribosome biogenesis|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.8|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.86|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.88|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.98|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.21|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.81|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kiaa0020|KIAA0020]]|0.468|
|[[:human genes:r:rpl17|RPL17]]|0.453|
|[[:human genes:c:c19orf53|C19orf53]]|0.435|
|[[:human genes:r:rpl31|RPL31]]|0.421|
|[[:human genes:m:mga|MGA]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 464/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|20/28|
|bone|16/26|
|breast|11/33|
|central nervous system|45/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|13/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|19/21|
|liver|17/20|
|lung|49/75|
|lymphocyte|12/16|
|ovary|17/26|
|pancreas|19/24|
|peripheral nervous system|10/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|17/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1039
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRTO4 Expression in NALM6 Cells: 6.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>