MS4A13 [The Human Chemical-Genetic Interaction Map Project]

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======= MS4A13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MS4A13
  * **<color #00a2e8>Official Name</color>**: membrane spanning 4-domains A13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=503497|503497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5J8X5|Q5J8X5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MS4A13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MS4A13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in signal transduction as a component of a multimeric receptor complex. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD20|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.28|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.96|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.92|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.9|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.42|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.38|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.37|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.32|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.31|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.3|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-2.21|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.2|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.18|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.13|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.12|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.07|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.06|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.05|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-2.02|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.01|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.96|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.94|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.89|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.87|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.81|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.8|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.77|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.76|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.74|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.73|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.72|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.72|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.77|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.79|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.8|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.83|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.86|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.91|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.93|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.93|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.98|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.99|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.03|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.05|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.09|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.09|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.13|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.17|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.24|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.24|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.25|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.33|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.34|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.54|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.55|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|2.94|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15446
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MS4A13 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>