MTFMT [The Human Chemical-Genetic Interaction Map Project]

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======= MTFMT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTFMT
  * **<color #00a2e8>Official Name</color>**: mitochondrial methionyl-tRNA formyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=123263|123263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DP5|Q96DP5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTFMT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTFMT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Formyl trans C|
|Formyl trans N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|charged-tRNA amino acid modification|
|methionyl-tRNA formyltransferase activity|
|conversion of methionyl-tRNA to N-formyl-methionyl-tRNA|
|tRNA modification|
|tRNA processing|
|translational initiation|
|RNA modification|
|tRNA metabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA processing|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.34|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.16|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.87|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.75|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.74|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.87|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gfm2|GFM2]]|0.449|
|[[:human genes:c:cox16|COX16]]|0.424|
|[[:human genes:m:mrps22|MRPS22]]|0.421|
|[[:human genes:c:c19orf70|C19orf70]]|0.41|
|[[:human genes:c:coa5|COA5]]|0.403|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3540
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTFMT Expression in NALM6 Cells: 4.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>