MTIF3 [The Human Chemical-Genetic Interaction Map Project]

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======= MTIF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTIF3
  * **<color #00a2e8>Official Name</color>**: mitochondrial translational initiation factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=219402|219402]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2K0|Q9H2K0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTIF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTIF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619554|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. {ECO:0000269|PubMed:12095986}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IF3 C|
|IF3 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial translational initiation|
|ribosome disassembly|
|ribonucleoprotein complex disassembly|
|ribosomal small subunit binding|
|translation factor activity, RNA binding|
|translation initiation factor activity|
|ribosome binding|
|organelle disassembly|
|mitochondrial translation|
|mitochondrial gene expression|
|translational initiation|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|translation|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.7|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.76|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.91|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.94|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.99|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.01|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.08|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.13|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.26|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.28|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.29|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.563|
|[[:human genes:c:c12orf65|C12orf65]]|0.509|
|[[:human genes:e:ears2|EARS2]]|0.504|
|[[:human genes:r:rpusd4|RPUSD4]]|0.498|
|[[:human genes:c:coq2|COQ2]]|0.493|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.493|
|[[:human genes:m:mrps21|MRPS21]]|0.486|
|[[:human genes:m:mrps24|MRPS24]]|0.485|
|[[:human genes:m:mrpl21|MRPL21]]|0.485|
|[[:human genes:v:vars2|VARS2]]|0.484|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.483|
|[[:human genes:s:sco2|SCO2]]|0.476|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.476|
|[[:human genes:m:mrpl47|MRPL47]]|0.475|
|[[:human genes:s:sars2|SARS2]]|0.473|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.472|
|[[:human genes:l:lars2|LARS2]]|0.471|
|[[:human genes:g:gfm2|GFM2]]|0.471|
|[[:human genes:y:yars2|YARS2]]|0.47|
|[[:human genes:p:pdss1|PDSS1]]|0.47|
|[[:human genes:f:fastkd5|FASTKD5]]|0.463|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.461|
|[[:human genes:m:mrps18a|MRPS18A]]|0.461|
|[[:human genes:g:gatc|GATC]]|0.46|
|[[:human genes:c:c17orf89|C17orf89]]|0.46|
|[[:human genes:p:pnpt1|PNPT1]]|0.46|
|[[:human genes:q:qrsl1|QRSL1]]|0.458|
|[[:human genes:m:mrps5|MRPS5]]|0.457|
|[[:human genes:m:mrpl23|MRPL23]]|0.456|
|[[:human genes:n:ndufa3|NDUFA3]]|0.456|
|[[:human genes:m:mrpl53|MRPL53]]|0.454|
|[[:human genes:p:pet117|PET117]]|0.453|
|[[:human genes:p:pars2|PARS2]]|0.452|
|[[:human genes:t:tars2|TARS2]]|0.452|
|[[:human genes:m:mrps16|MRPS16]]|0.451|
|[[:human genes:m:mtg1|MTG1]]|0.449|
|[[:human genes:r:rbfa|RBFA]]|0.448|
|[[:human genes:p:polg2|POLG2]]|0.448|
|[[:human genes:b:bcs1l|BCS1L]]|0.448|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.447|
|[[:human genes:c:cox6c|COX6C]]|0.445|
|[[:human genes:m:mrp63|MRP63]]|0.445|
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:d:dap3|DAP3]]|0.443|
|[[:human genes:t:tefm|TEFM]]|0.442|
|[[:human genes:n:ndufa2|NDUFA2]]|0.436|
|[[:human genes:f:fars2|FARS2]]|0.432|
|[[:human genes:m:mrps34|MRPS34]]|0.432|
|[[:human genes:r:rpusd3|RPUSD3]]|0.431|
|[[:human genes:c:coq3|COQ3]]|0.43|
|[[:human genes:c:cox7b|COX7B]]|0.428|
|[[:human genes:d:dars2|DARS2]]|0.428|
|[[:human genes:m:mtg2|MTG2]]|0.427|
|[[:human genes:s:slc25a26|SLC25A26]]|0.424|
|[[:human genes:m:mrps6|MRPS6]]|0.424|
|[[:human genes:c:coa6|COA6]]|0.422|
|[[:human genes:c:c10orf2|C10orf2]]|0.421|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.421|
|[[:human genes:n:ndufb11|NDUFB11]]|0.419|
|[[:human genes:n:ndufs7|NDUFS7]]|0.417|
|[[:human genes:a:atp5d|ATP5D]]|0.417|
|[[:human genes:m:mrpl15|MRPL15]]|0.417|
|[[:human genes:m:mrps23|MRPS23]]|0.415|
|[[:human genes:m:mrps26|MRPS26]]|0.414|
|[[:human genes:c:cars2|CARS2]]|0.413|
|[[:human genes:a:aars2|AARS2]]|0.412|
|[[:human genes:g:gfm1|GFM1]]|0.411|
|[[:human genes:t:tmem242|TMEM242]]|0.411|
|[[:human genes:n:nars2|NARS2]]|0.41|
|[[:human genes:n:ndufc2|NDUFC2]]|0.409|
|[[:human genes:m:mrpl12|MRPL12]]|0.406|
|[[:human genes:m:mrpl4|MRPL4]]|0.405|
|[[:human genes:m:mrps14|MRPS14]]|0.405|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.403|
|[[:human genes:m:mars2|MARS2]]|0.403|
|[[:human genes:m:mrps10|MRPS10]]|0.402|
|[[:human genes:t:tmem261|TMEM261]]|0.402|
|[[:human genes:m:mrps9|MRPS9]]|0.401|
|[[:human genes:p:pet112|PET112]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5507
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTIF3 Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>