MTMR3 [The Human Chemical-Genetic Interaction Map Project]

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======= MTMR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTMR3
  * **<color #00a2e8>Official Name</color>**: myotubularin related protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8897|8897]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13615|Q13615]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTMR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTMR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603558|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11676921}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FYVE|
|Myotub-related|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 5-phosphate metabolic process|
|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|
|regulation of phosphatidylinositol dephosphorylation|
|phosphatidylinositol-3-phosphatase activity|
|phosphatidylinositol dephosphorylation|
|phospholipid dephosphorylation|
|regulation of autophagosome assembly|
|regulation of vacuole organization|
|cellular response to glucose starvation|
|protein serine/threonine phosphatase activity|
|extrinsic component of membrane|
|regulation of phospholipid metabolic process|
|protein phosphatase binding|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|phosphatidylinositol biosynthetic process|
|cellular response to starvation|
|macroautophagy|
|phosphatidylinositol metabolic process|
|regulation of macroautophagy|
|response to starvation|
|lipid modification|
|glycerophospholipid biosynthetic process|
|regulation of dephosphorylation|
|protein dephosphorylation|
|regulation of organelle assembly|
|glycerolipid biosynthetic process|
|cellular response to nutrient levels|
|phospholipid biosynthetic process|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|glycerophospholipid metabolic process|
|dephosphorylation|
|regulation of autophagy|
|cellular response to external stimulus|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|lipid metabolic process|
|regulation of organelle organization|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.74|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4533
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTMR3 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>