MTPN [The Human Chemical-Genetic Interaction Map Project]

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======= MTPN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTPN
  * **<color #00a2e8>Official Name</color>**: myotrophin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=136319|136319]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58546|P58546]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTPN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTPN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606484|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {ECO:0000250, ECO:0000269|PubMed:10329199, ECO:0000269|PubMed:16895918, ECO:0000269|PubMed:20625546}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of barbed-end actin filament capping|
|cerebellar granular layer formation|
|cerebellar granule cell differentiation|
|F-actin capping protein complex|
|cerebellar granular layer morphogenesis|
|cerebellar granular layer development|
|cell differentiation in hindbrain|
|cerebellar cortex formation|
|cerebellar cortex morphogenesis|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of muscle hypertrophy|
|skeletal muscle tissue regeneration|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|cerebellar cortex development|
|regulation of actin filament depolymerization|
|regulation of cardiac muscle hypertrophy|
|regulation of muscle hypertrophy|
|tissue regeneration|
|cellular response to mechanical stimulus|
|regulation of protein depolymerization|
|phenol-containing compound metabolic process|
|regulation of muscle adaptation|
|cerebellum development|
|metencephalon development|
|regulation of protein complex disassembly|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|hindbrain development|
|positive regulation of NF-kappaB transcription factor activity|
|regeneration|
|positive regulation of cell growth|
|regulation of actin filament polymerization|
|central nervous system neuron differentiation|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|striated muscle cell differentiation|
|response to mechanical stimulus|
|regulation of protein polymerization|
|regulation of muscle system process|
|muscle cell differentiation|
|positive regulation of growth|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|axon|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|cellular response to external stimulus|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of translation|
|regulation of cellular component size|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|regulation of cellular amide metabolic process|
|regulation of cell growth|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|regulation of protein complex assembly|
|organic hydroxy compound metabolic process|
|muscle structure development|
|wound healing|
|regulation of anatomical structure size|
|posttranscriptional regulation of gene expression|
|regulation of cytoskeleton organization|
|response to wounding|
|regulation of system process|
|regulation of growth|
|perinuclear region of cytoplasm|
|brain development|
|head development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular component biogenesis|
|central nervous system development|
|neuron differentiation|
|response to abiotic stimulus|
|regulation of organelle organization|
|generation of neurons|
|neurogenesis|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.439|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17272
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTPN Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>