MUC1 [The Human Chemical-Genetic Interaction Map Project]

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======= MUC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MUC1
  * **<color #00a2e8>Official Name</color>**: mucin 1, cell surface associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4582|4582]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15941|P15941]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MUC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MUC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/158340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SEA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of histone H4 acetylation|
|negative regulation of transcription by competitive promoter binding|
|negative regulation of cell adhesion mediated by integrin|
|regulation of histone H4 acetylation|
|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|DNA damage response, signal transduction resulting in transcription|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of histone acetylation|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|positive regulation of peptidyl-lysine acetylation|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of protein acetylation|
|regulation of cell adhesion mediated by integrin|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|regulation of histone acetylation|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|O-glycan processing|
|regulation of peptidyl-lysine acetylation|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|p53 binding|
|signal transduction involved in DNA integrity checkpoint|
|regulation of protein acetylation|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|negative regulation of response to DNA damage stimulus|
|transcription coregulator activity|
|positive regulation of histone modification|
|mitotic DNA damage checkpoint|
|negative regulation of intrinsic apoptotic signaling pathway|
|Golgi lumen|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|positive regulation of chromatin organization|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|protein O-linked glycosylation|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|signal transduction by p53 class mediator|
|regulation of DNA-templated transcription in response to stress|
|DNA damage checkpoint|
|vesicle|
|DNA integrity checkpoint|
|regulation of histone modification|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cell cycle G1/S phase transition|
|positive regulation of chromosome organization|
|regulation of signal transduction by p53 class mediator|
|regulation of chromatin organization|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|nuclear chromatin|
|macromolecule glycosylation|
|protein glycosylation|
|activation of innate immune response|
|glycosylation|
|negative regulation of cell adhesion|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|apical plasma membrane|
|glycoprotein biosynthetic process|
|negative regulation of cell cycle process|
|positive regulation of innate immune response|
|regulation of chromosome organization|
|positive regulation of response to biotic stimulus|
|positive regulation of cell cycle|
|glycoprotein metabolic process|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|immune response-regulating signaling pathway|
|mitotic cell cycle process|
|positive regulation of response to external stimulus|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|activation of immune response|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|mitotic cell cycle|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|cell cycle process|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12306
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MUC1 Expression in NALM6 Cells: -1.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>