MYADM [The Human Chemical-Genetic Interaction Map Project]

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======= MYADM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYADM
  * **<color #00a2e8>Official Name</color>**: myeloid associated differentiation marker
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91663|91663]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96S97|Q96S97]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYADM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYADM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609959|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MARVEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein kinase C signaling|
|regulation of cell-cell adhesion involved in gastrulation|
|negative regulation of heterotypic cell-cell adhesion|
|cell-cell junction maintenance|
|cell junction maintenance|
|regulation of protein kinase C signaling|
|membrane raft organization|
|regulation of heterotypic cell-cell adhesion|
|establishment of endothelial barrier|
|regulation of gastrulation|
|positive regulation of substrate adhesion-dependent cell spreading|
|cellular component maintenance|
|endothelial cell development|
|cortical actin cytoskeleton|
|regulation of substrate adhesion-dependent cell spreading|
|negative regulation of actin filament polymerization|
|negative regulation of protein polymerization|
|endothelial cell differentiation|
|ruffle|
|endothelium development|
|positive regulation of cell-substrate adhesion|
|regulation of embryonic development|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|cell-cell junction organization|
|negative regulation of cytoskeleton organization|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of actin filament polymerization|
|cell-cell junction|
|negative regulation of cell-cell adhesion|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|protein localization to plasma membrane|
|epithelial cell development|
|regulation of cell-substrate adhesion|
|cell junction organization|
|regulation of protein polymerization|
|membrane raft|
|protein localization to cell periphery|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|regulation of cell morphogenesis involved in differentiation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|protein localization to membrane|
|regulation of cell morphogenesis|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of cell adhesion|
|epithelial cell differentiation|
|negative regulation of cellular component organization|
|molecular function|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|cell development|
|negative regulation of gene expression|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.93|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.82|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.76|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.75|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.82|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYADM Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>