MYBBP1A [The Human Chemical-Genetic Interaction Map Project]

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======= MYBBP1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYBBP1A
  * **<color #00a2e8>Official Name</color>**: MYB binding protein 1a
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10514|10514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQG0|Q9BQG0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYBBP1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYBBP1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604885|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. {ECO:0000250|UniProtKB:Q7TPV4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol phi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NLS-dependent protein nuclear import complex|
|positive regulation of anoikis|
|regulation of anoikis|
|cellular response to glucose starvation|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|E-box binding|
|circadian regulation of gene expression|
|positive regulation of gene expression, epigenetic|
|positive regulation of cell cycle arrest|
|regulation of cell cycle arrest|
|respiratory electron transport chain|
|signal transduction by p53 class mediator|
|osteoblast differentiation|
|circadian rhythm|
|intrinsic apoptotic signaling pathway|
|cellular response to starvation|
|cellular respiration|
|electron transport chain|
|response to starvation|
|cellular response to nutrient levels|
|energy derivation by oxidation of organic compounds|
|regulation of gene expression, epigenetic|
|transcription corepressor activity|
|ossification|
|cellular response to extracellular stimulus|
|rhythmic process|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|ribosome biogenesis|
|transcription factor binding|
|cellular response to external stimulus|
|positive regulation of cell cycle|
|sequence-specific DNA binding|
|generation of precursor metabolites and energy|
|ribonucleoprotein complex biogenesis|
|response to nutrient levels|
|response to extracellular stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|regulation of cell cycle process|
|nucleolus|
|apoptotic process|
|oxidation-reduction process|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 143/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|7/28|
|bone|2/26|
|breast|4/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|9/21|
|liver|4/20|
|lung|12/75|
|lymphocyte|2/16|
|ovary|8/26|
|pancreas|9/24|
|peripheral nervous system|4/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|11/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1261
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYBBP1A Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>