MYD88 [The Human Chemical-Genetic Interaction Map Project]

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======= MYD88 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYD88
  * **<color #00a2e8>Official Name</color>**: MYD88 innate immune signal transduction adaptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4615|4615]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99836|Q99836]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYD88&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYD88|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602170|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TIR domain binding|
|positive regulation of interleukin-23 production|
|Toll signaling pathway|
|Toll-like receptor binding|
|regulation of interleukin-23 production|
|cellular response to oxidised low-density lipoprotein particle stimulus|
|death receptor binding|
|toll-like receptor 9 signaling pathway|
|positive regulation of interleukin-17 production|
|positive regulation of cytokine production involved in inflammatory response|
|3-UTR-mediated mRNA stabilization|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|regulation of interleukin-17 production|
|MyD88-dependent toll-like receptor signaling pathway|
|regulation of cytokine production involved in inflammatory response|
|mRNA stabilization|
|RNA stabilization|
|positive regulation of interleukin-8 production|
|negative regulation of mRNA catabolic process|
|protein self-association|
|negative regulation of RNA catabolic process|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|regulation of interleukin-8 production|
|response to type I interferon|
|positive regulation of type I interferon production|
|negative regulation of mRNA metabolic process|
|cellular response to mechanical stimulus|
|defense response to Gram-positive bacterium|
|positive regulation of interleukin-6 production|
|interleukin-1-mediated signaling pathway|
|toll-like receptor signaling pathway|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|positive regulation of NF-kappaB transcription factor activity|
|cellular response to interleukin-1|
|regulation of mRNA stability|
|regulation of RNA stability|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|response to mechanical stimulus|
|endosome membrane|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of cellular catabolic process|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of catabolic process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of mRNA metabolic process|
|phagocytosis|
|defense response to bacterium|
|cellular response to external stimulus|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|defense response to other organism|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYD88 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>