MYH14 [The Human Chemical-Genetic Interaction Map Project]

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======= MYH14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH14
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79784|79784]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z406|Q7Z406]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608568|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADIP|
|Myosin tail 1|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin II filament|
|myosin II complex|
|actin-dependent ATPase activity|
|actomyosin|
|vocalization behavior|
|microfilament motor activity|
|mitochondrion morphogenesis|
|neuronal action potential|
|skeletal muscle contraction|
|multicellular organismal movement|
|musculoskeletal movement|
|brush border|
|transmission of nerve impulse|
|stress fiber|
|action potential|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|skeletal muscle tissue development|
|growth cone|
|skeletal muscle organ development|
|multicellular organismal signaling|
|sensory perception of sound|
|regulation of cell shape|
|sensory perception of mechanical stimulus|
|calmodulin binding|
|actin filament binding|
|ATPase activity|
|muscle contraction|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|regulation of membrane potential|
|mitochondrion organization|
|muscle structure development|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|cell part morphogenesis|
|actin filament-based process|
|behavior|
|cellular component morphogenesis|
|sensory perception|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|nervous system process|
|ATP binding|
|movement of cell or subcellular component|
|tissue development|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH14 Expression in NALM6 Cells: 2.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>