MYH3 [The Human Chemical-Genetic Interaction Map Project]

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======= MYH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH3
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4621|4621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11055|P11055]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Muscle contraction.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin tail 1|
|Myosin head|
|Myosin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin phosphatase activity|
|muscle myosin complex|
|myosin filament|
|microfilament motor activity|
|ATPase activity, coupled|
|skeletal muscle contraction|
|face morphogenesis|
|head morphogenesis|
|muscle filament sliding|
|actin-myosin filament sliding|
|multicellular organismal movement|
|musculoskeletal movement|
|body morphogenesis|
|sarcomere organization|
|face development|
|sarcomere|
|myofibril assembly|
|actin-mediated cell contraction|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|striated muscle cell development|
|muscle cell development|
|appendage morphogenesis|
|limb morphogenesis|
|appendage development|
|limb development|
|striated muscle cell differentiation|
|calmodulin binding|
|actin filament binding|
|ATP metabolic process|
|protein dephosphorylation|
|muscle cell differentiation|
|muscle contraction|
|muscle organ development|
|muscle system process|
|dephosphorylation|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|embryonic morphogenesis|
|actin filament-based process|
|organelle assembly|
|head development|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|cytoskeleton organization|
|ATP binding|
|movement of cell or subcellular component|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.93|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.72|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7992
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH3 Expression in NALM6 Cells: 3.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>