MYH9 [The Human Chemical-Genetic Interaction Map Project]

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======= MYH9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH9
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4627|4627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35579|P35579]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. {ECO:0000269|PubMed:20052411}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin N|
|Myosin tail 1|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of actin filament severing|
|negative regulation of actin filament severing|
|regulation of protein processing in phagocytic vesicle|
|uropod organization|
|positive regulation of protein processing in phagocytic vesicle|
|myosin II filament|
|regulation of plasma membrane repair|
|myosin II complex|
|actomyosin contractile ring|
|establishment of meiotic spindle localization|
|establishment of T cell polarity|
|establishment of lymphocyte polarity|
|actin-dependent ATPase activity|
|uropod|
|plasma membrane repair|
|actomyosin|
|meiotic spindle organization|
|protein membrane anchor|
|regulation of plasma membrane organization|
|monocyte differentiation|
|mononuclear cell differentiation|
|platelet formation|
|microfilament motor activity|
|platelet morphogenesis|
|myoblast fusion|
|membrane protein ectodomain proteolysis|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|blood vessel endothelial cell migration|
|cell-cell fusion|
|COP9 signalosome|
|cytokinetic process|
|syncytium formation by plasma membrane fusion|
|immunological synapse|
|membrane protein proteolysis|
|ADP binding|
|syncytium formation|
|cell leading edge|
|establishment of spindle localization|
|platelet aggregation|
|lysosome localization|
|motor activity|
|spindle localization|
|brush border|
|cleavage furrow|
|myotube differentiation|
|homotypic cell-cell adhesion|
|actin cytoskeleton reorganization|
|endothelial cell migration|
|regulation of protein processing|
|stress fiber|
|regulation of protein maturation|
|neuromuscular junction|
|epithelial cell migration|
|epithelium migration|
|ruffle|
|plasma membrane organization|
|tissue migration|
|integrin-mediated signaling pathway|
|cytokinesis|
|cell-cell adherens junction|
|actin filament-based movement|
|myeloid leukocyte differentiation|
|actomyosin structure organization|
|establishment of cell polarity|
|spindle|
|phagocytosis, engulfment|
|integrin binding|
|regulation of wound healing|
|platelet activation|
|plasma membrane invagination|
|membrane invagination|
|regulation of cell shape|
|spindle organization|
|meiotic cell cycle process|
|regulation of response to wounding|
|ameboidal-type cell migration|
|establishment or maintenance of cell polarity|
|striated muscle cell differentiation|
|calmodulin binding|
|actin filament binding|
|actin cytoskeleton|
|myeloid cell differentiation|
|meiotic cell cycle|
|ATPase activity|
|T cell activation|
|protein domain specific binding|
|muscle cell differentiation|
|actin binding|
|blood coagulation|
|coagulation|
|hemostasis|
|cadherin binding|
|angiogenesis|
|phagocytosis|
|leukocyte differentiation|
|positive regulation of proteolysis|
|establishment of organelle localization|
|in utero embryonic development|
|leukocyte migration|
|lymphocyte activation|
|regulation of actin filament-based process|
|blood vessel morphogenesis|
|focal adhesion|
|endomembrane system organization|
|microtubule cytoskeleton organization|
|muscle structure development|
|wound healing|
|blood vessel development|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|endocytosis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|actin filament-based process|
|response to wounding|
|organelle localization|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|microtubule-based process|
|import into cell|
|regulated exocytosis|
|cell morphogenesis|
|regulation of proteolysis|
|exocytosis|
|cellular component morphogenesis|
|tube development|
|membrane organization|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|cell cycle process|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|proteolysis|
|locomotion|
|cell cycle|
|RNA binding|
|reproductive process|
|reproduction|
|regulation of response to stress|
|ATP binding|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cell development|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.92|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.86|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.85|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 92/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|7/28|
|bone|0/26|
|breast|3/33|
|central nervous system|7/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5522
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH9 Expression in NALM6 Cells: 9.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>