MYLK3 [The Human Chemical-Genetic Interaction Map Project]

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======= MYLK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYLK3
  * **<color #00a2e8>Official Name</color>**: myosin light chain kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91807|91807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q32MK0|Q32MK0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYLK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYLK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612147|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sarcomerogenesis|
|positive regulation of sarcomere organization|
|myosin light chain kinase activity|
|regulation of vascular permeability involved in acute inflammatory response|
|regulation of sarcomere organization|
|calmodulin-dependent protein kinase activity|
|cardiac myofibril assembly|
|regulation of vascular permeability|
|sarcomere organization|
|positive regulation of striated muscle cell differentiation|
|cardiac muscle cell development|
|cardiac cell development|
|myofibril assembly|
|acute inflammatory response|
|positive regulation of organelle assembly|
|positive regulation of muscle cell differentiation|
|cardiac muscle cell differentiation|
|regulation of actomyosin structure organization|
|regulation of striated muscle cell differentiation|
|cellular component assembly involved in morphogenesis|
|actomyosin structure organization|
|cardiocyte differentiation|
|striated muscle cell development|
|muscle cell development|
|regulation of muscle cell differentiation|
|cardiac muscle tissue development|
|vascular process in circulatory system|
|cellular response to interleukin-1|
|positive regulation of supramolecular fiber organization|
|response to interleukin-1|
|striated muscle cell differentiation|
|actin cytoskeleton|
|regulation of organelle assembly|
|positive regulation of cytoskeleton organization|
|muscle cell differentiation|
|striated muscle tissue development|
|muscle tissue development|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|inflammatory response|
|positive regulation of cellular component biogenesis|
|heart development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|actin filament-based process|
|positive regulation of organelle organization|
|organelle assembly|
|cellular component morphogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|defense response|
|positive regulation of developmental process|
|ATP binding|
|cell development|
|tissue development|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.78|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.77|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.83|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.89|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.29|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nup54|NUP54]]|0.511|
|[[:human genes:i:igfn1|IGFN1]]|0.51|
|[[:human genes:s:sf3a3|SF3A3]]|0.475|
|[[:human genes:p:psma6|PSMA6]]|0.473|
|[[:human genes:c:copg1|COPG1]]|0.471|
|[[:human genes:e:exd1|EXD1]]|0.468|
|[[:human genes:v:vasn|VASN]]|0.464|
|[[:human genes:k:kctd17|KCTD17]]|0.459|
|[[:human genes:a:arcn1|ARCN1]]|0.458|
|[[:human genes:i:ints5|INTS5]]|0.457|
|[[:human genes:o:orc6|ORC6]]|0.451|
|[[:human genes:n:nup133|NUP133]]|0.448|
|[[:human genes:p:psma7|PSMA7]]|0.448|
|[[:human genes:c:chd4|CHD4]]|0.446|
|[[:human genes:a:aamp|AAMP]]|0.443|
|[[:human genes:t:tceb3c|TCEB3C]]|0.441|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.439|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.439|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.435|
|[[:human genes:c:ccna2|CCNA2]]|0.431|
|[[:human genes:r:rrm1|RRM1]]|0.431|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.429|
|[[:human genes:c:cln6|CLN6]]|0.427|
|[[:human genes:r:rbm39|RBM39]]|0.426|
|[[:human genes:k:kif3c|KIF3C]]|0.426|
|[[:human genes:c:copb1|COPB1]]|0.424|
|[[:human genes:o:orc1|ORC1]]|0.423|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.42|
|[[:human genes:a:akirin2|AKIRIN2]]|0.419|
|[[:human genes:g:golga6a|GOLGA6A]]|0.417|
|[[:human genes:s:sap30bp|SAP30BP]]|0.416|
|[[:human genes:p:pole|POLE]]|0.416|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.416|
|[[:human genes:a:ankle1|ANKLE1]]|0.415|
|[[:human genes:r:rrn3|RRN3]]|0.415|
|[[:human genes:p:pan3|PAN3]]|0.414|
|[[:human genes:g:gid4|GID4]]|0.407|
|[[:human genes:s:slc6a17|SLC6A17]]|0.406|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.405|
|[[:human genes:i:iscu|ISCU]]|0.405|
|[[:human genes:d:dtl|DTL]]|0.405|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.404|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.404|
|[[:human genes:p:psmb2|PSMB2]]|0.404|
|[[:human genes:m:mms22l|MMS22L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYLK3 Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>