MYLK [The Human Chemical-Genetic Interaction Map Project]

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======= MYLK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYLK
  * **<color #00a2e8>Official Name</color>**: myosin light chain kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4638|4638]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15746|Q15746]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYLK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYLK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600922|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Pkinase Tyr|
|ig|
|Pkinase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aorta smooth muscle tissue morphogenesis|
|myosin light chain kinase activity|
|cellular hypotonic response|
|hypotonic response|
|bleb assembly|
|tonic smooth muscle contraction|
|smooth muscle tissue development|
|aorta morphogenesis|
|cellular response to osmotic stress|
|aorta development|
|smooth muscle contraction|
|positive regulation of wound healing|
|cleavage furrow|
|artery morphogenesis|
|positive regulation of response to wounding|
|stress fiber|
|response to osmotic stress|
|muscle tissue morphogenesis|
|artery development|
|muscle organ morphogenesis|
|positive regulation of calcium ion transport|
|regulation of wound healing|
|regulation of response to wounding|
|lamellipodium|
|calmodulin binding|
|actin cytoskeleton|
|protein kinase activity|
|regulation of calcium ion transport|
|muscle contraction|
|actin binding|
|positive regulation of ion transport|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of metal ion transport|
|blood vessel morphogenesis|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|muscle structure development|
|blood vessel development|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|tissue morphogenesis|
|tube morphogenesis|
|regulation of ion transport|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of cell motility|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|phosphorylation|
|regulation of response to stress|
|ATP binding|
|cellular response to stress|
|tissue development|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11912
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYLK Expression in NALM6 Cells: 8.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>