MYO1H [The Human Chemical-Genetic Interaction Map Project]

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======= MYO1H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO1H
  * **<color #00a2e8>Official Name</color>**: myosin IH
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283446|283446]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1T3|Q8N1T3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO1H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO1H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614636|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin TH1|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin complex|
|motor activity|
|actin binding|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.1|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.7|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.72|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.75|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.75|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.8|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.86|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.88|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.89|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.91|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.97|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.98|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.13|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.51|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.564|
|[[:human genes:c:c14orf93|C14orf93]]|0.55|
|[[:human genes:c:cdc73|CDC73]]|0.54|
|[[:human genes:v:vasn|VASN]]|0.529|
|[[:human genes:p:psmc2|PSMC2]]|0.527|
|[[:human genes:z:znf106|ZNF106]]|0.525|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.519|
|[[:human genes:p:psmd11|PSMD11]]|0.515|
|[[:human genes:d:dtl|DTL]]|0.511|
|[[:human genes:r:rps2|RPS2]]|0.51|
|[[:human genes:e:exosc9|EXOSC9]]|0.509|
|[[:human genes:c:cope|COPE]]|0.508|
|[[:human genes:c:chd4|CHD4]]|0.508|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.506|
|[[:human genes:p:psma6|PSMA6]]|0.504|
|[[:human genes:c:cbwd5|CBWD5]]|0.504|
|[[:human genes:c:cbwd3|CBWD3]]|0.501|
|[[:human genes:s:scaf1|SCAF1]]|0.5|
|[[:human genes:s:smg7|SMG7]]|0.5|
|[[:human genes:r:ranbp2|RANBP2]]|0.499|
|[[:human genes:m:mt1e|MT1E]]|0.497|
|[[:human genes:t:tfip11|TFIP11]]|0.496|
|[[:human genes:p:psmc1|PSMC1]]|0.495|
|[[:human genes:r:rrp15|RRP15]]|0.494|
|[[:human genes:c:ccna2|CCNA2]]|0.494|
|[[:human genes:n:nbpf10|NBPF10]]|0.491|
|[[:human genes:p:psmc6|PSMC6]]|0.49|
|[[:human genes:s:smg1|SMG1]]|0.488|
|[[:human genes:t:tceb3c|TCEB3C]]|0.488|
|[[:human genes:p:psmd1|PSMD1]]|0.483|
|[[:human genes:c:copg1|COPG1]]|0.483|
|[[:human genes:r:rrn3|RRN3]]|0.48|
|[[:human genes:p:psmd14|PSMD14]]|0.479|
|[[:human genes:c:copa|COPA]]|0.479|
|[[:human genes:c:cbwd6|CBWD6]]|0.477|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.477|
|[[:human genes:n:npipb5|NPIPB5]]|0.476|
|[[:human genes:t:twistnb|TWISTNB]]|0.476|
|[[:human genes:t:trim52|TRIM52]]|0.475|
|[[:human genes:m:med17|MED17]]|0.475|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.473|
|[[:human genes:r:rbm39|RBM39]]|0.473|
|[[:human genes:p:paf1|PAF1]]|0.472|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.471|
|[[:human genes:o:orc6|ORC6]]|0.47|
|[[:human genes:a:aqr|AQR]]|0.47|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.47|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.47|
|[[:human genes:s:snrpa1|SNRPA1]]|0.469|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.468|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.467|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.466|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.466|
|[[:human genes:r:rnf113a|RNF113A]]|0.465|
|[[:human genes:f:fbxo5|FBXO5]]|0.465|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.465|
|[[:human genes:p:pwp2|PWP2]]|0.463|
|[[:human genes:m:myt1l|MYT1L]]|0.463|
|[[:human genes:p:psmd7|PSMD7]]|0.462|
|[[:human genes:s:ssh2|SSH2]]|0.461|
|[[:human genes:p:prpf8|PRPF8]]|0.46|
|[[:human genes:u:upf1|UPF1]]|0.459|
|[[:human genes:c:cdc6|CDC6]]|0.459|
|[[:human genes:g:golga8o|GOLGA8O]]|0.458|
|[[:human genes:n:nop16|NOP16]]|0.454|
|[[:human genes:p:pola2|POLA2]]|0.454|
|[[:human genes:r:rfxank|RFXANK]]|0.454|
|[[:human genes:s:supt6h|SUPT6H]]|0.453|
|[[:human genes:t:ticrr|TICRR]]|0.452|
|[[:human genes:r:rad51|RAD51]]|0.452|
|[[:human genes:o:or10g3|OR10G3]]|0.451|
|[[:human genes:c:cgb2|CGB2]]|0.45|
|[[:human genes:a:akirin2|AKIRIN2]]|0.45|
|[[:human genes:c:cnot1|CNOT1]]|0.45|
|[[:human genes:c:cdc45|CDC45]]|0.448|
|[[:human genes:s:sf3a1|SF3A1]]|0.446|
|[[:human genes:n:nol12|NOL12]]|0.445|
|[[:human genes:d:ddtl|DDTL]]|0.444|
|[[:human genes:s:syt9|SYT9]]|0.444|
|[[:human genes:p:psmb4|PSMB4]]|0.443|
|[[:human genes:r:rnf4|RNF4]]|0.443|
|[[:human genes:l:lrr1|LRR1]]|0.442|
|[[:human genes:k:kctd17|KCTD17]]|0.441|
|[[:human genes:a:ahctf1|AHCTF1]]|0.441|
|[[:human genes:p:psmc5|PSMC5]]|0.441|
|[[:human genes:c:chmp2a|CHMP2A]]|0.44|
|[[:human genes:c:copz1|COPZ1]]|0.44|
|[[:human genes:t:terf2|TERF2]]|0.44|
|[[:human genes:n:napa|NAPA]]|0.439|
|[[:human genes:s:stil|STIL]]|0.439|
|[[:human genes:a:acsf2|ACSF2]]|0.438|
|[[:human genes:r:rfpl3|RFPL3]]|0.438|
|[[:human genes:r:rbbp5|RBBP5]]|0.437|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.437|
|[[:human genes:r:rps3a|RPS3A]]|0.437|
|[[:human genes:a:ankle2|ANKLE2]]|0.436|
|[[:human genes:a:arcn1|ARCN1]]|0.436|
|[[:human genes:c:cnpy3|CNPY3]]|0.435|
|[[:human genes:c:copb2|COPB2]]|0.435|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.434|
|[[:human genes:z:znf655|ZNF655]]|0.433|
|[[:human genes:r:rps12|RPS12]]|0.433|
|[[:human genes:s:slc4a1|SLC4A1]]|0.433|
|[[:human genes:p:psmb1|PSMB1]]|0.432|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.432|
|[[:human genes:d:disp2|DISP2]]|0.431|
|[[:human genes:c:cactin|CACTIN]]|0.431|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.431|
|[[:human genes:s:s1pr4|S1PR4]]|0.43|
|[[:human genes:k:kif3c|KIF3C]]|0.429|
|[[:human genes:w:wdr87|WDR87]]|0.428|
|[[:human genes:g:gprin2|GPRIN2]]|0.428|
|[[:human genes:b:bysl|BYSL]]|0.428|
|[[:human genes:n:nup85|NUP85]]|0.427|
|[[:human genes:r:rpl14|RPL14]]|0.427|
|[[:human genes:c:ccdc94|CCDC94]]|0.426|
|[[:human genes:o:orc1|ORC1]]|0.425|
|[[:human genes:m:myh2|MYH2]]|0.425|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.424|
|[[:human genes:c:chaf1a|CHAF1A]]|0.422|
|[[:human genes:p:prss8|PRSS8]]|0.422|
|[[:human genes:m:mms22l|MMS22L]]|0.421|
|[[:human genes:p:pan3|PAN3]]|0.421|
|[[:human genes:u:ubap1|UBAP1]]|0.419|
|[[:human genes:p:psmd3|PSMD3]]|0.419|
|[[:human genes:c:col2a1|COL2A1]]|0.418|
|[[:human genes:c:ccdc116|CCDC116]]|0.418|
|[[:human genes:n:npipb8|NPIPB8]]|0.418|
|[[:human genes:s:sec13|SEC13]]|0.418|
|[[:human genes:c:ctr9|CTR9]]|0.417|
|[[:human genes:e:elmod3|ELMOD3]]|0.416|
|[[:human genes:p:pcf11|PCF11]]|0.416|
|[[:human genes:w:wdr75|WDR75]]|0.416|
|[[:human genes:i:ik|IK]]|0.415|
|[[:human genes:n:ndc1|NDC1]]|0.415|
|[[:human genes:c:copb1|COPB1]]|0.414|
|[[:human genes:r:rpl30|RPL30]]|0.414|
|[[:human genes:n:nupl1|NUPL1]]|0.414|
|[[:human genes:r:rps14|RPS14]]|0.413|
|[[:human genes:h:hmgcr|HMGCR]]|0.413|
|[[:human genes:u:utp20|UTP20]]|0.411|
|[[:human genes:b:b3gnt3|B3GNT3]]|0.41|
|[[:human genes:a:ankle1|ANKLE1]]|0.41|
|[[:human genes:m:myb|MYB]]|0.41|
|[[:human genes:m:mdm2|MDM2]]|0.41|
|[[:human genes:p:psmb2|PSMB2]]|0.409|
|[[:human genes:r:rffl|RFFL]]|0.409|
|[[:human genes:c:crnkl1|CRNKL1]]|0.408|
|[[:human genes:h:hap1|HAP1]]|0.407|
|[[:human genes:s:slc6a17|SLC6A17]]|0.407|
|[[:human genes:c:cox8a|COX8A]]|0.407|
|[[:human genes:c:cacna1a|CACNA1A]]|0.407|
|[[:human genes:f:fam25b|FAM25B]]|0.407|
|[[:human genes:m:med14|MED14]]|0.406|
|[[:human genes:w:wdr46|WDR46]]|0.405|
|[[:human genes:r:rpl35|RPL35]]|0.405|
|[[:human genes:n:nsf|NSF]]|0.405|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.405|
|[[:human genes:k:kpnb1|KPNB1]]|0.405|
|[[:human genes:g:gosr2|GOSR2]]|0.404|
|[[:human genes:e:exosc4|EXOSC4]]|0.404|
|[[:human genes:c:cmya5|CMYA5]]|0.403|
|[[:human genes:p:psmc4|PSMC4]]|0.402|
|[[:human genes:c:c3orf22|C3orf22]]|0.401|
|[[:human genes:a:aamp|AAMP]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|3/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2122
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO1H Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>