MYOCD [The Human Chemical-Genetic Interaction Map Project]

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======= MYOCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYOCD
  * **<color #00a2e8>Official Name</color>**: myocardin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93649|93649]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZQ8|Q8IZQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYOCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYOCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606127|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). {ECO:0000250, ECO:0000269|PubMed:12640126}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAP|
|RPEL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cardiac vascular smooth muscle cell differentiation|
|regulation of cell growth by extracellular stimulus|
|regulation of cardiac vascular smooth muscle cell differentiation|
|positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|
|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|
|urinary bladder development|
|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|
|ductus arteriosus closure|
|RNA polymerase II-specific DNA-binding transcription factor binding|
|positive regulation of transcription from RNA polymerase II promoter involved in heart development|
|negative regulation of skeletal muscle cell differentiation|
|positive regulation of vascular smooth muscle cell differentiation|
|negative regulation of vascular associated smooth muscle cell migration|
|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|
|regulation of phenotypic switching|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|negative regulation of amyloid-beta clearance|
|cardiac muscle cell myoblast differentiation|
|positive regulation of smooth muscle cell differentiation|
|negative regulation of skeletal muscle tissue development|
|cardioblast differentiation|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|vascular smooth muscle cell differentiation|
|regulation of vascular smooth muscle cell differentiation|
|regulation of transcription from RNA polymerase II promoter involved in heart development|
|ventricular cardiac muscle cell differentiation|
|regulation of amyloid-beta clearance|
|negative regulation of vascular smooth muscle cell proliferation|
|positive regulation of cardiac muscle cell differentiation|
|regulation of skeletal muscle cell differentiation|
|negative regulation of myotube differentiation|
|negative regulation of smooth muscle cell migration|
|regulation of vascular associated smooth muscle cell migration|
|uterus development|
|negative regulation of cardiac muscle cell apoptotic process|
|regulation of platelet-derived growth factor receptor signaling pathway|
|R-SMAD binding|
|negative regulation of striated muscle cell apoptotic process|
|positive regulation of cardiocyte differentiation|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|histone acetyltransferase binding|
|negative regulation of cyclin-dependent protein kinase activity|
|positive regulation of smooth muscle contraction|
|regulation of smooth muscle cell differentiation|
|smooth muscle cell differentiation|
|myoblast differentiation|
|regulation of cardiac muscle cell differentiation|
|regulation of cardiac muscle cell apoptotic process|
|negative regulation of muscle cell apoptotic process|
|negative regulation of striated muscle cell differentiation|
|regulation of striated muscle cell apoptotic process|
|lung alveolus development|
|positive regulation of cardiac muscle tissue development|
|negative regulation of smooth muscle cell proliferation|
|positive regulation of muscle contraction|
|cellular component maintenance|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of skeletal muscle tissue development|
|regulation of vascular smooth muscle cell proliferation|
|regulation of cardiocyte differentiation|
|negative regulation of muscle tissue development|
|regulation of myoblast differentiation|
|negative regulation of muscle cell differentiation|
|regulation of histone acetylation|
|positive regulation of DNA binding|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|regulation of smooth muscle contraction|
|regulation of smooth muscle cell migration|
|artery morphogenesis|
|regulation of peptidyl-lysine acetylation|
|vasculogenesis|
|regulation of muscle cell apoptotic process|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|regulation of protein acetylation|
|regulation of cardiac muscle tissue development|
|artery development|
|positive regulation of muscle cell differentiation|
|cardiac muscle cell differentiation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of striated muscle cell differentiation|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|histone deacetylase binding|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|cardiocyte differentiation|
|regulation of DNA binding|
|cardiac ventricle development|
|digestive tract development|
|regulation of striated muscle tissue development|
|negative regulation of protein serine/threonine kinase activity|
|regulation of smooth muscle cell proliferation|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|digestive system development|
|regulation of histone modification|
|regulation of muscle cell differentiation|
|stem cell differentiation|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|lung development|
|cardiac chamber development|
|respiratory tube development|
|positive regulation of binding|
|positive regulation of vasculature development|
|regulation of chromatin organization|
|respiratory system development|
|striated muscle cell differentiation|
|negative regulation of protein kinase activity|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of muscle system process|
|nuclear chromatin|
|muscle cell differentiation|
|negative regulation of kinase activity|
|negative regulation of cell migration|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to extracellular stimulus|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|striated muscle tissue development|
|renal system development|
|transcription coactivator activity|
|muscle tissue development|
|negative regulation of cellular component movement|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of locomotion|
|transcription factor binding|
|cellular response to external stimulus|
|response to hypoxia|
|regulation of chromosome organization|
|response to decreased oxygen levels|
|regulation of binding|
|response to oxygen levels|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|regulation of cell growth|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|heart development|
|response to extracellular stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|regulation of system process|
|negative regulation of protein modification process|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|negative regulation of cell differentiation|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3482
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYOCD Expression in NALM6 Cells: -1.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>