NAA10 [The Human Chemical-Genetic Interaction Map Project]

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======= NAA10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AA10
  * **<color #00a2e8>Official Name</color>**: N-alpha-acetyltransferase 10, NatA catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8260|8260]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41227|P41227]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAA10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAA10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300013|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acetyltransf 1|
|FR47|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of maintenance of mitotic sister chromatid cohesion, centromeric|
|negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric|
|N-terminal peptidyl-serine acetylation|
|peptidyl-serine acetylation|
|peptide-glutamate-N-acetyltransferase activity|
|peptide-serine-N-acetyltransferase activity|
|N-terminal peptidyl-glutamic acid acetylation|
|negative regulation of maintenance of mitotic sister chromatid cohesion|
|negative regulation of maintenance of sister chromatid cohesion|
|regulation of centromeric sister chromatid cohesion|
|NatA complex|
|negative regulation of sister chromatid cohesion|
|regulation of maintenance of mitotic sister chromatid cohesion|
|regulation of maintenance of sister chromatid cohesion|
|N-acetyltransferase activity|
|peptide alpha-N-acetyltransferase activity|
|N-terminal protein amino acid acetylation|
|acetyltransferase activity|
|regulation of sister chromatid cohesion|
|N-terminal protein amino acid modification|
|peptidyl-glutamic acid modification|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|ribosome binding|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|intracellular|
|regulation of chromosome segregation|
|internal protein amino acid acetylation|
|negative regulation of chromosome organization|
|protein acetylation|
|regulation of mitotic nuclear division|
|DNA packaging|
|protein acylation|
|regulation of nuclear division|
|peptidyl-serine modification|
|protein maturation|
|DNA conformation change|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|nucleolus|
|peptidyl-amino acid modification|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.51|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.35|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.24|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.03|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.93|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.88|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.85|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.84|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.75|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.75|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 652/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/26|
|bone|26/26|
|breast|27/30|
|central nervous system|44/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|18/18|
|liver|16/19|
|lung|66/72|
|lymphocyte|15/16|
|ovary|24/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|13/20|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|23/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 38
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAA10 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>