NAALADL1 [The Human Chemical-Genetic Interaction Map Project]

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======= NAALADL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AALADL1
  * **<color #00a2e8>Official Name</color>**: N-acetylated alpha-linked acidic dipeptidase like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10004|10004]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQQ1|Q9UQQ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAALADL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAALADL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFR dimer|
|PA|
|Peptidase M28|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|carboxypeptidase activity|
|aminopeptidase activity|
|peptide catabolic process|
|metallopeptidase activity|
|peptidase activity|
|apical plasma membrane|
|peptide metabolic process|
|calcium ion binding|
|cellular amide metabolic process|
|zinc ion binding|
|protein homodimerization activity|
|organonitrogen compound catabolic process|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.513|
|[[:human genes:p:polr2j3|POLR2J3]]|0.478|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.464|
|[[:human genes:i:ik|IK]]|0.456|
|[[:human genes:t:tceb3c|TCEB3C]]|0.451|
|[[:human genes:a:ankle2|ANKLE2]]|0.44|
|[[:human genes:z:znf655|ZNF655]]|0.433|
|[[:human genes:p:psmb4|PSMB4]]|0.431|
|[[:human genes:c:ccna2|CCNA2]]|0.426|
|[[:human genes:k:kctd17|KCTD17]]|0.42|
|[[:human genes:i:igfn1|IGFN1]]|0.418|
|[[:human genes:p:psmc2|PSMC2]]|0.416|
|[[:human genes:p:psmd1|PSMD1]]|0.412|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.412|
|[[:human genes:z:zfand5|ZFAND5]]|0.411|
|[[:human genes:p:ppfia4|PPFIA4]]|0.407|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.405|
|[[:human genes:n:narfl|NARFL]]|0.405|
|[[:human genes:t:twistnb|TWISTNB]]|0.402|
|[[:human genes:x:xylt2|XYLT2]]|0.4|
|[[:human genes:p:psma6|PSMA6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2192
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAALADL1 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>