NADK [The Human Chemical-Genetic Interaction Map Project]

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======= NADK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/ADK
  * **<color #00a2e8>Official Name</color>**: N/AD kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65220|65220]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95544|O95544]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NADK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NADK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611616|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAD kinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADP biosynthetic process|
|NAD+ kinase activity|
|NADP metabolic process|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide biosynthetic process|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|nicotinamide nucleotide metabolic process|
|pyridine nucleotide metabolic process|
|pyridine-containing compound biosynthetic process|
|pyridine-containing compound metabolic process|
|NAD metabolic process|
|oxidoreduction coenzyme metabolic process|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of insulin secretion|
|positive regulation of peptide hormone secretion|
|positive regulation of hormone secretion|
|coenzyme biosynthetic process|
|regulation of insulin secretion|
|ATP metabolic process|
|regulation of peptide hormone secretion|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|organophosphate metabolic process|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of protein localization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-3.24|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.23|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.16|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.36|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.21|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.09|
|[[:results:exp539|42°C R08 exp539]]|-2|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.96|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.89|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.22|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NADK Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>