NAMPT [The Human Chemical-Genetic Interaction Map Project]

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======= NAMPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AMPT
  * **<color #00a2e8>Official Name</color>**: nicotinamide phosphoribosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10135|10135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43490|P43490]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAMPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAMPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608764|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAPRTase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nicotinamide phosphoribosyltransferase activity|
|response to D-galactose|
|nicotinate-nucleotide diphosphorylase (carboxylating) activity|
|regulation of lung blood pressure|
|response to oxygen-glucose deprivation|
|cellular response to oxygen-glucose deprivation|
|NAD biosynthesis via nicotinamide riboside salvage pathway|
|positive regulation of nitric-oxide synthase biosynthetic process|
|negative regulation of cellular senescence|
|regulation of nitric-oxide synthase biosynthetic process|
|negative regulation of cell aging|
|NAD biosynthetic process|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide biosynthetic process|
|pyridine nucleotide metabolic process|
|nicotinamide nucleotide metabolic process|
|adipose tissue development|
|pyridine-containing compound biosynthetic process|
|glial cell activation|
|cellular response to amyloid-beta|
|regulation of cellular senescence|
|neuroinflammatory response|
|pyridine-containing compound metabolic process|
|regulation of cell aging|
|response to amyloid-beta|
|macrophage activation|
|oxidoreduction coenzyme metabolic process|
|neuron death|
|drug binding|
|circadian regulation of gene expression|
|cellular response to ionizing radiation|
|negative regulation of autophagy|
|positive regulation of smooth muscle cell proliferation|
|insulin receptor signaling pathway|
|regulation of smooth muscle cell proliferation|
|coenzyme biosynthetic process|
|circadian rhythm|
|response to hexose|
|response to ionizing radiation|
|response to monosaccharide|
|cellular response to insulin stimulus|
|response to carbohydrate|
|cytokine activity|
|cellular response to radiation|
|female pregnancy|
|regulation of blood pressure|
|cellular response to decreased oxygen levels|
|multi-multicellular organism process|
|cofactor biosynthetic process|
|cellular response to oxygen levels|
|connective tissue development|
|response to insulin|
|cellular response to nutrient levels|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|negative regulation of cellular catabolic process|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|rhythmic process|
|aging|
|negative regulation of catabolic process|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to peptide|
|regulation of autophagy|
|cellular response to external stimulus|
|response to decreased oxygen levels|
|response to oxygen levels|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|nuclear speck|
|cofactor metabolic process|
|response to radiation|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|response to nutrient levels|
|inflammatory response|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cell junction|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|negative regulation of developmental process|
|multi-organism reproductive process|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|cell death|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|defense response|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.07|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.88|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.76|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.71|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|6/28|
|bone|0/26|
|breast|8/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 818
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAMPT Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>