NAPA [The Human Chemical-Genetic Interaction Map Project]

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======= NAPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/APA
  * **<color #00a2e8>Official Name</color>**: NSF attachment protein alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8775|8775]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54920|P54920]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603215|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|soluble NSF attachment protein activity|
|SNARE complex disassembly|
|synaptobrevin 2-SNAP-25-syntaxin-1a complex|
|regulation of synaptic vesicle priming|
|apical protein localization|
|synaptic vesicle priming|
|vacuolar membrane|
|synaptic transmission, glutamatergic|
|intra-Golgi vesicle-mediated transport|
|SNARE complex|
|syntaxin binding|
|positive regulation of ATPase activity|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|synaptic vesicle exocytosis|
|SNARE binding|
|vesicle coating|
|exocytic process|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|regulation of synaptic vesicle exocytosis|
|regulation of ATPase activity|
|postsynapse|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|vesicle targeting|
|presynapse|
|vesicle budding from membrane|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|membrane fusion|
|cellular protein complex disassembly|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|signal release|
|establishment of vesicle localization|
|neurotransmitter transport|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of exocytosis|
|protein-containing complex disassembly|
|protein-containing complex binding|
|vesicle organization|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|establishment of organelle localization|
|Golgi vesicle transport|
|cellular component disassembly|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|synaptic signaling|
|regulation of vesicle-mediated transport|
|organelle localization|
|Golgi membrane|
|regulated exocytosis|
|brain development|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|head development|
|exocytosis|
|regulation of secretion|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|central nervous system development|
|intracellular protein transport|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cell-cell signaling|
|secretion|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.7|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.56|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.44|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.39|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.24|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.21|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.06|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.02|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.9|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.9|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.76|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.78|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.8|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.82|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.82|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.88|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.95|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|2.13|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.23|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.23|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:iscu|ISCU]]|0.544|
|[[:human genes:c:chd4|CHD4]]|0.532|
|[[:human genes:s:supt5h|SUPT5H]]|0.508|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.506|
|[[:human genes:t:tceb3c|TCEB3C]]|0.501|
|[[:human genes:c:copg1|COPG1]]|0.496|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.495|
|[[:human genes:c:copa|COPA]]|0.494|
|[[:human genes:s:slc4a1|SLC4A1]]|0.493|
|[[:human genes:e:exosc9|EXOSC9]]|0.493|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.492|
|[[:human genes:c:crnkl1|CRNKL1]]|0.485|
|[[:human genes:c:cdh24|CDH24]]|0.48|
|[[:human genes:o:orc6|ORC6]]|0.478|
|[[:human genes:c:cactin|CACTIN]]|0.477|
|[[:human genes:f:fam160a1|FAM160A1]]|0.476|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.475|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.471|
|[[:human genes:d:disp2|DISP2]]|0.471|
|[[:human genes:a:aamp|AAMP]]|0.471|
|[[:human genes:u:utp3|UTP3]]|0.47|
|[[:human genes:p:psmc5|PSMC5]]|0.466|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.465|
|[[:human genes:m:mbtd1|MBTD1]]|0.464|
|[[:human genes:p:psmb4|PSMB4]]|0.462|
|[[:human genes:s:slc6a17|SLC6A17]]|0.462|
|[[:human genes:t:tsg101|TSG101]]|0.461|
|[[:human genes:t:tfip11|TFIP11]]|0.46|
|[[:human genes:t:trappc11|TRAPPC11]]|0.459|
|[[:human genes:v:vasn|VASN]]|0.458|
|[[:human genes:k:kif3c|KIF3C]]|0.458|
|[[:human genes:p:psmd11|PSMD11]]|0.457|
|[[:human genes:c:cbwd3|CBWD3]]|0.457|
|[[:human genes:c:copb1|COPB1]]|0.454|
|[[:human genes:d:dtl|DTL]]|0.454|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.452|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.451|
|[[:human genes:p:polr2d|POLR2D]]|0.45|
|[[:human genes:s:sec13|SEC13]]|0.448|
|[[:human genes:c:cbwd6|CBWD6]]|0.446|
|[[:human genes:c:cgb2|CGB2]]|0.444|
|[[:human genes:a:aqr|AQR]]|0.444|
|[[:human genes:r:rpl30|RPL30]]|0.443|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.443|
|[[:human genes:p:psma6|PSMA6]]|0.442|
|[[:human genes:r:ranbp2|RANBP2]]|0.442|
|[[:human genes:p:psmd3|PSMD3]]|0.441|
|[[:human genes:f:fam25b|FAM25B]]|0.441|
|[[:human genes:p:pole|POLE]]|0.441|
|[[:human genes:r:rps2|RPS2]]|0.44|
|[[:human genes:n:nol10|NOL10]]|0.44|
|[[:human genes:m:myo1h|MYO1H]]|0.439|
|[[:human genes:t:ticrr|TICRR]]|0.439|
|[[:human genes:p:psmd7|PSMD7]]|0.439|
|[[:human genes:n:narfl|NARFL]]|0.439|
|[[:human genes:c:cbwd5|CBWD5]]|0.437|
|[[:human genes:i:itgax|ITGAX]]|0.437|
|[[:human genes:k:krt78|KRT78]]|0.436|
|[[:human genes:t:trappc2l|TRAPPC2L]]|0.436|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.436|
|[[:human genes:w:wdr75|WDR75]]|0.436|
|[[:human genes:c:ccna2|CCNA2]]|0.436|
|[[:human genes:z:znf219|ZNF219]]|0.436|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.436|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.436|
|[[:human genes:v:vps54|VPS54]]|0.436|
|[[:human genes:m:myt1l|MYT1L]]|0.435|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.435|
|[[:human genes:h:hivep3|HIVEP3]]|0.434|
|[[:human genes:a:arcn1|ARCN1]]|0.433|
|[[:human genes:p:pola1|POLA1]]|0.433|
|[[:human genes:p:psmb2|PSMB2]]|0.433|
|[[:human genes:r:rad51|RAD51]]|0.432|
|[[:human genes:g:golga8o|GOLGA8O]]|0.431|
|[[:human genes:r:rps12|RPS12]]|0.43|
|[[:human genes:c:chaf1a|CHAF1A]]|0.43|
|[[:human genes:g:gosr2|GOSR2]]|0.43|
|[[:human genes:s:syt9|SYT9]]|0.43|
|[[:human genes:c:copz1|COPZ1]]|0.43|
|[[:human genes:m:myo18a|MYO18A]]|0.429|
|[[:human genes:c:cdca3|CDCA3]]|0.427|
|[[:human genes:k:kctd17|KCTD17]]|0.425|
|[[:human genes:c:c14orf93|C14orf93]]|0.425|
|[[:human genes:z:zfand5|ZFAND5]]|0.425|
|[[:human genes:r:rbm8a|RBM8A]]|0.425|
|[[:human genes:r:rbm39|RBM39]]|0.424|
|[[:human genes:s:snrpa1|SNRPA1]]|0.424|
|[[:human genes:m:mms22l|MMS22L]]|0.422|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.422|
|[[:human genes:o:orc1|ORC1]]|0.422|
|[[:human genes:r:rfc1|RFC1]]|0.42|
|[[:human genes:p:polr2l|POLR2L]]|0.419|
|[[:human genes:t:tpx2|TPX2]]|0.418|
|[[:human genes:p:psmd8|PSMD8]]|0.418|
|[[:human genes:d:dhx38|DHX38]]|0.418|
|[[:human genes:s:smg7|SMG7]]|0.417|
|[[:human genes:t:tuba8|TUBA8]]|0.417|
|[[:human genes:n:nxf1|NXF1]]|0.416|
|[[:human genes:g:gar1|GAR1]]|0.416|
|[[:human genes:n:nupl1|NUPL1]]|0.415|
|[[:human genes:p:psap|PSAP]]|0.415|
|[[:human genes:p:psmc1|PSMC1]]|0.415|
|[[:human genes:c:cdc73|CDC73]]|0.414|
|[[:human genes:a:atp1a3|ATP1A3]]|0.414|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.413|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.413|
|[[:human genes:e:exosc6|EXOSC6]]|0.413|
|[[:human genes:g:golga6b|GOLGA6B]]|0.413|
|[[:human genes:r:rfpl3|RFPL3]]|0.412|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.412|
|[[:human genes:s:sf3a3|SF3A3]]|0.411|
|[[:human genes:n:nufip2|NUFIP2]]|0.41|
|[[:human genes:r:rpl10a|RPL10A]]|0.41|
|[[:human genes:s:snip1|SNIP1]]|0.41|
|[[:human genes:p:plk4|PLK4]]|0.41|
|[[:human genes:n:nup153|NUP153]]|0.41|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.41|
|[[:human genes:r:rpl35|RPL35]]|0.409|
|[[:human genes:d:ddtl|DDTL]]|0.409|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.408|
|[[:human genes:t:tspy8|TSPY8]]|0.408|
|[[:human genes:a:akirin2|AKIRIN2]]|0.408|
|[[:human genes:r:rbbp5|RBBP5]]|0.406|
|[[:human genes:w:wdr87|WDR87]]|0.406|
|[[:human genes:o:osbp|OSBP]]|0.405|
|[[:human genes:g:gid4|GID4]]|0.404|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.404|
|[[:human genes:m:mt1e|MT1E]]|0.403|
|[[:human genes:n:npipb5|NPIPB5]]|0.403|
|[[:human genes:m:med14|MED14]]|0.402|
|[[:human genes:p:psmd6|PSMD6]]|0.402|
|[[:human genes:y:ythdc1|YTHDC1]]|0.402|
|[[:human genes:z:znf830|ZNF830]]|0.402|
|[[:human genes:a:arhgef15|ARHGEF15]]|0.402|
|[[:human genes:u:ubap1|UBAP1]]|0.402|
|[[:human genes:e:exosc4|EXOSC4]]|0.401|
|[[:human genes:n:nup160|NUP160]]|0.401|
|[[:human genes:g:golga6a|GOLGA6A]]|0.401|
|[[:human genes:r:rps10|RPS10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 562/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|26/28|
|bone|21/26|
|breast|27/33|
|central nervous system|40/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|12/16|
|kidney|16/21|
|liver|13/20|
|lung|55/75|
|lymphocyte|14/16|
|ovary|25/26|
|pancreas|15/24|
|peripheral nervous system|8/16|
|plasma cell|15/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|19/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 605
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAPA Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>