NAPG [The Human Chemical-Genetic Interaction Map Project]

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======= NAPG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/APG
  * **<color #00a2e8>Official Name</color>**: NSF attachment protein gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8774|8774]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99747|Q99747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAPG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAPG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603216|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|soluble NSF attachment protein activity|
|vacuolar membrane|
|intra-Golgi vesicle-mediated transport|
|SNARE complex|
|syntaxin binding|
|membrane fusion|
|protein stabilization|
|synapse|
|regulation of protein stability|
|lysosomal membrane|
|Golgi vesicle transport|
|membrane organization|
|intracellular protein transport|
|mitochondrion|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-2.14|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.81|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.74|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.71|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.75|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 186/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|7/28|
|bone|5/26|
|breast|6/33|
|central nervous system|13/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|5/21|
|liver|4/20|
|lung|23/75|
|lymphocyte|5/16|
|ovary|9/26|
|pancreas|10/24|
|peripheral nervous system|1/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|4/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAPG Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>