NBAS [The Human Chemical-Genetic Interaction Map Project]

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======= NBAS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NBAS
  * **<color #00a2e8>Official Name</color>**: NBAS subunit of NRZ tethering complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51594|51594]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A2RRP1|A2RRP1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NBAS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NBAS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608025|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are associated with short stature, optic nerve atrophy, and Pelger-Huet anomaly. [provided by RefSeq, Oct 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). {ECO:0000269|PubMed:19369418, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec39|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Dsl1/NZR complex|
|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|SNARE binding|
|negative regulation of mRNA metabolic process|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|Golgi vesicle transport|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|regulation of catabolic process|
|endoplasmic reticulum|
|macromolecule catabolic process|
|negative regulation of RNA metabolic process|
|negative regulation of nucleobase-containing compound metabolic process|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|nitrogen compound transport|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.22|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.21|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.2|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.93|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.89|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.86|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 82/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|4/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|3/21|
|liver|3/20|
|lung|6/75|
|lymphocyte|4/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2838
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NBAS Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>