NBL1 [The Human Chemical-Genetic Interaction Map Project]

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======= NBL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NBL1
  * **<color #00a2e8>Official Name</color>**: NBL1, DAN family BMP antagonist
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4681|4681]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41271|P41271]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NBL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NBL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600613|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cys knot|
|DAN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of BMP from receptor via BMP binding|
|sequestering of BMP in extracellular matrix|
|determination of dorsal identity|
|negative regulation of monocyte chemotaxis|
|determination of dorsal/ventral asymmetry|
|maintenance of protein location in extracellular region|
|morphogen activity|
|negative regulation of mononuclear cell migration|
|sequestering of extracellular ligand from receptor|
|extracellular negative regulation of signal transduction|
|BMP binding|
|extracellular regulation of signal transduction|
|negative regulation of leukocyte chemotaxis|
|regulation of monocyte chemotaxis|
|negative regulation of leukocyte migration|
|regulation of mononuclear cell migration|
|negative regulation of BMP signaling pathway|
|negative regulation of chemotaxis|
|dorsal/ventral pattern formation|
|regulation of BMP signaling pathway|
|maintenance of protein location|
|regulation of leukocyte chemotaxis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|determination of bilateral symmetry|
|specification of symmetry|
|negative regulation of cellular response to growth factor stimulus|
|maintenance of location|
|protein localization to extracellular region|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of cell migration|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regionalization|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|pattern specification process|
|negative regulation of immune system process|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|neuron projection development|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|generation of neurons|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7416
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NBL1 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>