NBPF12 [The Human Chemical-Genetic Interaction Map Project]

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======= NBPF12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NBPF12
  * **<color #00a2e8>Official Name</color>**: NBPF member 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=149013|149013]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TAG4|Q5TAG4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NBPF12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NBPF12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608607|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1220|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.3|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.19|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.16|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.09|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.83|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.79|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.72|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.77|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.83|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.83|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.89|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.13|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.21|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.27|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 718/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|23/26|
|breast|32/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NBPF12 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>