NCAPH2 [The Human Chemical-Genetic Interaction Map Project]

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======= NCAPH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCAPH2
  * **<color #00a2e8>Official Name</color>**: non-SMC condensin II complex subunit H2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29781|29781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6IBW4|Q6IBW4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCAPH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCAPH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1032|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|female meiosis chromosome separation|
|mitotic sister chromatid separation|
|meiotic chromosome condensation|
|female meiosis chromosome segregation|
|condensin complex|
|mitotic chromosome condensation|
|meiotic chromosome separation|
|condensed chromosome|
|female meiotic nuclear division|
|chromosome separation|
|chromosome condensation|
|T cell differentiation in thymus|
|intercellular bridge|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|mitotic sister chromatid segregation|
|female gamete generation|
|T cell differentiation|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|meiotic cell cycle process|
|DNA packaging|
|nuclear chromosome segregation|
|meiotic cell cycle|
|T cell activation|
|lymphocyte differentiation|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|leukocyte differentiation|
|cellular process involved in reproduction in multicellular organism|
|lymphocyte activation|
|chromatin binding|
|cell junction|
|hemopoiesis|
|mitotic cell cycle process|
|hematopoietic or lymphoid organ development|
|immune system development|
|mitotic cell cycle|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|leukocyte activation|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cell activation|
|cell cycle|
|reproductive process|
|reproduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.31|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.16|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.02|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.99|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.81|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.77|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.72|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.19|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.2|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 407/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|20/28|
|blood|10/28|
|bone|13/26|
|breast|21/33|
|central nervous system|37/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|14/21|
|liver|10/20|
|lung|46/75|
|lymphocyte|6/16|
|ovary|15/26|
|pancreas|10/24|
|peripheral nervous system|7/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|15/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|10/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2220
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCAPH2 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>