NCK1 [The Human Chemical-Genetic Interaction Map Project]

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======= NCK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCK1
  * **<color #00a2e8>Official Name</color>**: NCK adaptor protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4690|4690]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16333|P16333]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|SH2|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cap-dependent translational initiation|
|regulation of cap-dependent translational initiation|
|eukaryotic initiation factor eIF2 binding|
|regulation of cap-independent translational initiation|
|positive regulation of cap-independent translational initiation|
|positive regulation of translation in response to endoplasmic reticulum stress|
|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|
|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|
|positive regulation of cytoplasmic translational initiation|
|regulation of cytoplasmic translational initiation|
|negative regulation of PERK-mediated unfolded protein response|
|positive regulation of translation in response to stress|
|regulation of translation in response to endoplasmic reticulum stress|
|signal complex assembly|
|regulation of PERK-mediated unfolded protein response|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|substrate-dependent cell migration, cell extension|
|protein phosphatase type 1 complex|
|positive regulation of cytoplasmic translation|
|negative regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of transcription from RNA polymerase II promoter in response to stress|
|cytoskeletal adaptor activity|
|peptidyl-serine dephosphorylation|
|regulation of translation in response to stress|
|receptor signaling complex adaptor activity|
|regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of peptidyl-serine phosphorylation|
|substrate-dependent cell migration|
|protein kinase inhibitor activity|
|ephrin receptor binding|
|vesicle membrane|
|positive regulation of translational initiation|
|regulation of cytoplasmic translation|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|lamellipodium assembly|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|positive regulation of response to endoplasmic reticulum stress|
|lamellipodium organization|
|negative regulation of response to endoplasmic reticulum stress|
|ribosome|
|SH3/SH2 adaptor activity|
|receptor tyrosine kinase binding|
|positive regulation of intrinsic apoptotic signaling pathway|
|regulation of insulin receptor signaling pathway|
|vascular endothelial growth factor receptor signaling pathway|
|regulation of cellular response to insulin stimulus|
|protein binding, bridging|
|regulation of translational initiation|
|regulation of response to endoplasmic reticulum stress|
|ephrin receptor signaling pathway|
|positive regulation of actin filament polymerization|
|positive regulation of T cell proliferation|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|positive regulation of translation|
|positive regulation of protein polymerization|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|positive regulation of leukocyte proliferation|
|regulation of peptidyl-serine phosphorylation|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of cellular amide metabolic process|
|regulation of T cell proliferation|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of actin filament polymerization|
|cell-cell junction|
|positive regulation of apoptotic signaling pathway|
|T cell receptor signaling pathway|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|protein dephosphorylation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of cytoskeleton organization|
|regulation of leukocyte proliferation|
|regulation of protein polymerization|
|negative regulation of protein kinase activity|
|T cell activation|
|actin filament organization|
|Fc receptor signaling pathway|
|protein domain specific binding|
|negative regulation of kinase activity|
|positive regulation of protein complex assembly|
|positive regulation of cell-cell adhesion|
|response to endoplasmic reticulum stress|
|regulation of actin filament organization|
|negative regulation of transferase activity|
|positive regulation of neuron projection development|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|dephosphorylation|
|cadherin binding|
|regulation of T cell activation|
|phagocytosis|
|signaling receptor binding|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of translation|
|positive regulation of lymphocyte activation|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|lymphocyte activation|
|regulation of actin filament-based process|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of neurogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|posttranscriptional regulation of gene expression|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|actin filament-based process|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.25|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.21|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.92|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.81|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.79|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.81|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.48|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:btk|BTK]]|0.539|
|[[:human genes:b:blnk|BLNK]]|0.472|
|[[:human genes:p:plcg2|PLCG2]]|0.446|
|[[:human genes:v:vav1|VAV1]]|0.411|
|[[:human genes:e:elof1|ELOF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCK1 Expression in NALM6 Cells: 4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>