NCLN [The Human Chemical-Genetic Interaction Map Project]

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======= NCLN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCLN
  * **<color #00a2e8>Official Name</color>**: nicalin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56926|56926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969V3|Q969V3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCLN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCLN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609156|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nicastrin|
|Peptidase M28|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein complex stability|
|protein stabilization|
|regulation of protein stability|
|regulation of protein complex assembly|
|protein-containing complex|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.55|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.54|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.21|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.01|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.82|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.8|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.78|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.71|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.72|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.87|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.93|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.45|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.78|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|4.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmem147|TMEM147]]|0.494|
|[[:human genes:c:ccdc47|CCDC47]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4520
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCLN Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>