NDC80 [The Human Chemical-Genetic Interaction Map Project]

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======= NDC80 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDC80
  * **<color #00a2e8>Official Name</color>**: NDC80 kinetochore complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10403|10403]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14777|O14777]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDC80&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDC80|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607272|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:9315664}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ndc80 HEC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ndc80 complex|
|positive regulation of protein localization to kinetochore|
|condensed nuclear chromosome outer kinetochore|
|regulation of protein localization to kinetochore|
|positive regulation of spindle checkpoint|
|positive regulation of mitotic cell cycle spindle assembly checkpoint|
|condensed nuclear chromosome kinetochore|
|positive regulation of cell cycle checkpoint|
|attachment of mitotic spindle microtubules to kinetochore|
|regulation of mitotic spindle checkpoint|
|regulation of spindle checkpoint|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|kinetochore organization|
|attachment of spindle microtubules to kinetochore|
|establishment of mitotic spindle orientation|
|regulation of cell cycle checkpoint|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|establishment of spindle localization|
|mitotic metaphase plate congression|
|spindle localization|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|chromosome, centromeric region|
|metaphase plate congression|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|establishment of chromosome localization|
|chromosome localization|
|mitotic spindle organization|
|regulation of sister chromatid segregation|
|kinetochore|
|condensed chromosome kinetochore|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|establishment of cell polarity|
|sister chromatid segregation|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|spindle organization|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|establishment or maintenance of cell polarity|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|establishment of organelle localization|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|regulation of cellular protein localization|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|regulation of cellular localization|
|cell cycle process|
|regulation of protein localization|
|chromosome organization|
|identical protein binding|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.35|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.17|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.72|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.7|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.71|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.73|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.75|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.76|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.81|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.83|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.85|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.9|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.91|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.93|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.93|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.99|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2.02|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.04|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.07|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.16|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.18|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.24|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.27|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.27|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.3|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.32|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.38|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.42|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|2.64|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.72|
|[[:results:exp16|DABN 2μM R00 exp16]]|3.12|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf93|C14orf93]]|0.49|
|[[:human genes:d:dtl|DTL]]|0.479|
|[[:human genes:c:cdc73|CDC73]]|0.469|
|[[:human genes:c:cmya5|CMYA5]]|0.467|
|[[:human genes:n:nop16|NOP16]]|0.465|
|[[:human genes:k:krt78|KRT78]]|0.454|
|[[:human genes:r:rps2|RPS2]]|0.454|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.448|
|[[:human genes:p:psmc5|PSMC5]]|0.436|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.433|
|[[:human genes:a:atxn1|ATXN1]]|0.432|
|[[:human genes:f:fam160a1|FAM160A1]]|0.428|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.427|
|[[:human genes:v:vasn|VASN]]|0.425|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.423|
|[[:human genes:m:mdm2|MDM2]]|0.423|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.423|
|[[:human genes:a:ankle2|ANKLE2]]|0.422|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.422|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.422|
|[[:human genes:t:twistnb|TWISTNB]]|0.421|
|[[:human genes:p:polr2j3|POLR2J3]]|0.42|
|[[:human genes:t:tpx2|TPX2]]|0.418|
|[[:human genes:s:srrm2|SRRM2]]|0.416|
|[[:human genes:t:trim52|TRIM52]]|0.416|
|[[:human genes:t:topbp1|TOPBP1]]|0.416|
|[[:human genes:x:xylt2|XYLT2]]|0.414|
|[[:human genes:n:nupl1|NUPL1]]|0.413|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.412|
|[[:human genes:s:supt5h|SUPT5H]]|0.412|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.412|
|[[:human genes:l:lad1|LAD1]]|0.41|
|[[:human genes:t:ticrr|TICRR]]|0.41|
|[[:human genes:p:ppfia4|PPFIA4]]|0.409|
|[[:human genes:u:uqcrh|UQCRH]]|0.409|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.409|
|[[:human genes:c:ccna2|CCNA2]]|0.407|
|[[:human genes:a:aamp|AAMP]]|0.407|
|[[:human genes:s:s1pr4|S1PR4]]|0.407|
|[[:human genes:d:dock6|DOCK6]]|0.405|
|[[:human genes:p:plk1|PLK1]]|0.405|
|[[:human genes:g:golga8o|GOLGA8O]]|0.405|
|[[:human genes:p:paf1|PAF1]]|0.403|
|[[:human genes:l:loc643669|LOC643669]]|0.402|
|[[:human genes:s:sec13|SEC13]]|0.401|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.4|
|[[:human genes:p:psma6|PSMA6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 721/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 238
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDC80 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>